Human p53 database and software

Database

The p53 database contains information on nearly 5,867 mutations found in the human p53 gene. The database itself has been updated in April of 1997.

The database contains information on the cancer type, loss of heterozygosity, base position, amino acid position, amino acid change, local DNA sequence,citation, and other items.

The database itself is in the dBASE format.

Software

Routines have been developed for the analysis of single base substitutions, including programs to:

• (i) determine if two mutational spectra are different,
• (ii) determine if mutations show a DNA strand bias,
• (iii) determine the frequency of transitions and transversions,
• (iv) examine the number of mutations and mutable sites in each exon,
• (v) display the number and kind of mutations observed at each base in the coding region,
• (vi) perform nearest neighbor analysis, and
• (vii) display mutable amino acids in the hprt protein.

The software runs only on IBM-compatible PCs.

Note that you are required to supply your complete postal address in exchange for the password necessary to run the software.

Availability

If you wish, you can download the p53 database and software.

References

1. Cariello NF et al. Database and software for the analysis of mutations in the human p53 gene. Cancer Research, 54, 4454-4460, 1994.
2. Cariello NF et al. Database and software for the analysis of mutations at the human p53 gene. Nucleic Acids Research, 22, 3549-3550, 1994.
3. Cariello NF, Douglas GR and Soussi T. Databases and software for the analysis of mutations in the human p53 gene, the human hprt gene and the lacZ gene in transgenic rodents. Nucl. Acids Res., 24, 119-120, 1996.