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[SANET-MG] hierarchical metabolomics a public relations dream
I understand, from reading the entire report, that genetic
modification to enhance inulin fructan production in potato resulted in
unforeseen metabolic changes that differed between GM and parental lines
but those changes were comparable to the differences among cutlivars of
potato. The paper concludes "The cultivar-based compositional
heterogeneity we describe emphasizes the importance of comparison with a
range of equivalent cultivars and not solely the parental line." What
seems to be advocated is that when unexpected differences appear between
parental lines and GM crops then just scoot over and find some potato
cultivars that do show differences.
Published online before print September 26, 2005
Proc. Natl. Acad. Sci. USA, 10.1073/pnas.0503955102
Hierarchical metabolomics demonstrates substantial compositional
similarity between genetically modified and conventional potato crops
Gareth S. Catchpole *, Manfred Beckmann , David P. Enot , Madhav Mondhe
, Britta Zywicki *, Janet Taylor ¶, Nigel Hardy , Aileen Smith , Ross D.
King , Douglas B. Kell ||, Oliver Fiehn *, and John Draper **
*Max Planck Institute for Molecular Plant Physiology, D-14424 Golm,
Germany; and Institute of Biological Sciences and Department of Computer
Science, University of Wales, Aberystwyth SY23 3DA, United Kingdom
There is current debate whether genetically modified (GM) plants might
contain unexpected, potentially undesirable changes in overall
metabolite composition. However, appropriate analytical technology and
acceptable metrics of compositional similarity require development. We
describe a comprehensive comparison of total metabolites in field-grown
GM and conventional potato tubers using a hierarchical approach
initiating with rapid metabolome "fingerprinting" to guide more detailed
profiling of metabolites where significant differences are suspected.
Central to this strategy are data analysis procedures able to generate
validated, reproducible metrics of comparison from complex metabolome
data. We show that, apart from targeted changes, these GM potatoes in
this study appear substantially equivalent to traditional cultivars.
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