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[SANET-MG] organic strawberries for cancer chemotherapy
There has been some discussion pointing out that there are not many
science studies directly on the evaluation of human health comparisons
of organic and conventional foods. That is certainly a problem that
should be addressed by research granting agencies and not left to
funding by industry. The paper shows another way of dealing with the
health benefits of organic foods. In that study extracts of organic
strawberries were more effective than convention berries in inhibiting
cancer cell proliferation.Legitimate health studies may be the most
effective way to promote organic agriculture.
J. Agric. Food Chem., 54 (4), 1248 -1255, 2006. 10.1021/jf0524776
Web Release Date: January 21, 2006
Antioxidant Levels and Inhibition of Cancer Cell Proliferation in Vitro
by Extracts from Organically and Conventionally Cultivated Strawberries
Marie E. Olsson,* C. Staffan Andersson, Stina Oredsson, Rakel H.
Berglund, and Karl-Erik Gustavsson
The effects of extracts from five cultivars of strawberries on the
proliferation of colon cancer cells HT29 and breast cancer cells MCF-7
were investigated, and possible correlations with the levels of several
antioxidants were analyzed. In addition, the effects of organic
cultivation compared to conventional cultivation on the content of
antioxidants in the strawberries and strawberry extracts on the cancer
cell proliferation were investigated. The ratio of ascorbate to
dehydroascorbate was significantly higher in the organically cultivated
strawberries. The strawberry extracts decreased the proliferation of
both HT29 cells and MCF-7 cells in a dose-dependent way. The inhibitory
effect for the highest concentration of the extracts was in the range of
41-63% (average 53%) inhibition compared to controls for the HT29 cells
and 26-56% (average 43%) for MCF-7 cells. The extracts from organically
grown strawberries had a higher antiproliferative activity for both cell
types at the highest concentration than the conventionally grown, and
this might indicate a higher content of secondary metabolites with
anticarcinogenic properties in the organically grown strawberries. For
HT29 cells, there was a negative correlation at the highest extract
concentration between the content of ascorbate or vitamin C and cancer
cell proliferation, whereas for MCF-7 cells, a high ratio of ascorbate
to dehydroascorbate correlated with a higher inhibition of cell
proliferation at the second highest concentration. The significance of
the effect of ascorbate on cancer cell proliferation might lie in a
synergistic action with other compounds
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