07 April 1997 This p53 database update contains information on 5867 human p53 mutants and has been updated in April 1997. You should take the files in this subdirectory (...\P53\UPDATE) only if you ALREADY HAVE a working version of the p53 database and software. The OPTIONS/ABOUT screen should say Analysis Program, Version 1.1, 1995. The files contained in the self-extracting archive 53UPDATE.EXE will update the database. If you do not have a working version of the p53 database, you should take the files in the ...\P53\PROGRAM subdirectory. The 53UPDATE.EXE file must be transferred from this server as a binary file. After downloading 53UPDATE.EXE from this server, copy the file to the subdirectory where your version of the p53 database and software exist on your IBM-compatible machine. Uncompress the file by typing: 53UPDATE from the DOS prompt or double-click on the 53UPDATE.EXE file using the Windows File Manager The uncompression program will ask you if you want to overwrite the existing files. You MUST answer YES to all overwrites. You WANT TO OVERWRITE all existing files. You should then be ready to go with the new version of the database. Please let me know if you have problems. Digitally, Neal Cariello cariello@sunsite.unc.edu