>From bronze!sol.ctr.columbia.edu!spool.mu.edu!uwm.edu!bionet!EMBL-HEIDELBERG.DE!Des.Higgins Thu Sep  5 07:51:03 EST 1991
Article: 1286 of bionet.software
Path: bronze!sol.ctr.columbia.edu!spool.mu.edu!uwm.edu!bionet!EMBL-HEIDELBERG.DE!Des.Higgins
>From: Des.Higgins@EMBL-HEIDELBERG.DE (Des Higgins)
Newsgroups: bionet.software
Subject: Clustal V: new version of Clustal available.
Message-ID: <F1150630A040C719@EMBL-Heidelberg.DE>
Date: 5 Sep 91 09:09:00 GMT
Article-I.D.: EMBL-Hei.F1150630A040C719
Sender: news@genbank.bio.net
Distribution: bionet
Lines: 49


Clustal V: software for multiple sequence alignment now available from the
           EMBL file server.




The CLUSTAL package of programs for multiple sequence alignment has been 
completely rewritten in C and is now available from the EMBL file server.

The package quickly and flexibly aligns large numbers of nucleic acid or
protein sequences.   It is completely menu driven and on-line help is
provided.

Many new features have been added including:

- improved sequence input (automatically detect and read NBRF/PIR, FASTA and 
  EMBL/SWISSPROT formats); 

- a choice of 4 output formats (old Clustal, GCG .msf, NBRF/PIR and Phylip);

- phylogenetic trees after alignment using the Neighbor-Joining method of 
  Saitou and Nei with a bootstrap option to calculate confidence intervals;

- the ability to align old alignments with each other;

- a full command line interface;

- improved portability; with 1 change to 1 header file, the code will compile
  and run on the following systems:  IBM PC (Turbo C); VAX/VMS C; Apple Mac 
  (Think C); Decstation (Ultrix C) and Sun (Gnu C, but not the native Sun C).



To get the package, send a mail message with the following words: "help" and
"help software" on 2 lines with no quotes to the address:

                Netserv@EMBL-Heidelberg.DE


If you have any queries regarding the package, please mail Des Higgins at the
address:   Higgins@EMBL-Heidelberg.DE


Des Higgins and Rainer Fuchs
EMBL Data Library, Heidelberg, Germany.

Alan Bleasby
Daresbury, UK.



