Subject: NIH Guide, Vol 20., No. 5, February l, l99l Part 2
From: Dot Baker <[email-masked]>
To: [email-masked]
Date: Wed, 30 Jan 91 14:37 EST

Hi Paul,
   This is the second item coming to you from the NIH Guide 2/l/9l.
  Please notify me when posted.   Thanks.
                                         Dottie
 ---------------------------- Text of forwarded message -----------------------
 
X-comment: NIH Guide (including TOC) contained 24 pages (1920 lines)
X-comment: RFAS described:  AI-91-04, AI-91-05, AI-91-06, HD-91-05, CA-91-05,
                            DK-91-03, AD-91-01, HD-91-01
OBJECTIVES AND SCOPE
 
The emphases of this initiative are threefold:  (1) to attract new scientific
expertise into the study of the basic mechanisms of kidney and urological
diseases; (2) to encourage interdisciplinary research; and (3) to extend these
basic investigations into innovative clinical and epidemiologic studies of the
causes, therapy, and prevention of kidney and urologic diseases and disorders.
In approaching the study of these disease processes, it is anticipated that
extensive collaboration will be required between individuals in the basic
sciences, including cell biology, molecular biology, immunology, genetics,
epidemiology, biochemistry, physiology, and pathology with clinical sciences.
It is the expressed intent of the announcement to attract into the study of
kidney and urologic disorders new investigators not currently active in this
field and to explore new basic areas that may have clinical research
application.  Individual institutions with both basic and clinical research
capabilities are eligible to apply.  Inter-institutional collaborative
research arrangements are also appropriate and are encouraged.

 
            NIH GUIDE - Vol. 20, No. 5, February 1, 1991 - Page 17
SPECIAL INSTRUCTIONS FOR INCLUSION OF WOMEN AND MINORITIES IN CLINICAL
RESEARCH STUDIES
 
For projects involving clinical research, NIH requires applicants to give
special attention to the inclusion of women and minorities in study
populations.  If women or minorities are not included in the study populations
for clinical studies, a specific justification for this exclusion must be
provided.  Applications without such documentation will not be accepted for
review.
 
MECHANISM OF SUPPORT
 
NIDDK expects to award up to six center grants (P50) in fiscal year 1992 on a
competitive basis.  The receipt of up to six competitive continuation
applications from those centers who are current awardees is anticipated.
These applications will compete for awards along with other applications
received in response to this announcement.  Foreign institutions are not
eligible to apply.  The anticipated awards are for five years and are
contingent upon the availability of appropriated funds.  The total amount of
available funds to support this program (including both direct and indirect
costs) is anticipated to be no more than $4.2 million per year.  No applicant
may request more than $750,000 in total costs (both direct and indirect costs)
in the initial budget period.
 
The complete Request for Applications (RFA) and consultation may be obtained
from:
 
Dr. Ralph L. Bain
Kidney and Urology Research Centers Program Director
DKUHD/NIDDK
Federal Building, Room 102
9000 Rockville Pike
Bethesda, MD  20892
Telephone:  (301) 496-8218
 
REVIEW PROCEDURES
 
Applications for an award of a research center grant will be evaluated in a
national competition by the NIH peer review process.  Applications will be
reviewed initially by a special review committee convened by the NIDDK and
subsequently by the National Diabetes and Digestive and Kidney Diseases
Advisory Council.
 
METHOD OF APPLYING
 
Potential applicants are urged to submit a letter of intent to the Program
Director by March 15, 1991, regarding their application.  The letter of intent
is nonbinding and is not a precondition for an award.  The letter of intent
should include the name(s) of the Principal Investigator(s), principal
collaborators, a descriptive title of the proposed research center, and the
organization(s) involved.  Applications must be submitted using PHS Form 398
(Rev. 10/88).  The RFA label contained in the application kit must be affixed
to the bottom of the face page of the original copy of the application.
Failure to use this label could result in delayed processing and review of the
application.  Complete line 2 of the application face page by inserting the
title and number of this RFA and checking the YES box.
 
Mail the completed application (original and four copies) to:
 
Application Receipt Office
Division of Research Grants
Westwood Building, Room 240
National Institutes of Health
Bethesda, MD  20892**
 
Simultaneously submit two copies to:
 
Review Branch, NIDDK
5333 Westbard Avenue
Westwood Building, Room 406
Bethesda, MD  20892
 
The special single receipt date for submissions in response to this
announcement is July 16, 1991, with earliest funding August 1, 1992.
 
This program is described in the Catalog of Federal Domestic Assistance No.
93.849, Kidney, Urologic, and Hematologic Diseases Research.  Awards will be
made under the authority of the Public Health Service Act, Title III, Section
 
            NIH GUIDE - Vol. 20, No. 5, February 1, 1991 - Page 18
301 (Public Law 78-410, as amended; 42 USC 241) and administered under PHS
grant policies and Federal Regulations 42 CFR Part 52 and 45 CFR Part 74.
This program is not subject to the intergovernmental review requirements of
Executive Order 12372 or Health Systems Agency review.

SCIENCE EDUCATION PARTNERSHIP AWARD
 
RFA AVAILABLE:  ADAMHA  AD-91-01
                NIH     OD-91-01
 
P.T. 44; K.W. 0720000, 0710000
 
Alcohol, Drug Abuse, and Mental Health Administration
National Institutes of Health
 
Letter of Intent Receipt Date:  March 15, 1991
Application Receipt Date:  April 25, 1991
 
BACKGROUND INFORMATION
 
The President and the Nation's Governors have declared six "National Education
Goals," one of which is that by the year 2000, students in the United States
will be the world leaders in science and mathematics achievement.  Further,
unless there are adequate numbers of students entering and remaining in the
mathematics and scientific fields of education, the United States will not
have a sufficient supply of scientists, engineers, and technicians to meet the
Nation's future workforce needs.  There is also the need for a scientifically
literate society that understands the role of science, biology, and
technology.  There is a lack of public understanding of behaviors that
increase the risk for disease, the use of animals in behavioral and biomedical
research, and the necessity for basic research to make progress toward
improving health.  To help address these issues, the Alcohol, Drug Abuse, and
Mental Health Administration (ADAMHA) and the National Institutes of Health
(NIH) are initiating in Fiscal Year 1991 the Science Education Partnership
Award (SEPA) Program.  To meet their respective missions, the ADAMHA and the
NIH are issuing this joint Request for Applications (RFA) for SEPA proposals.
Applicants may submit multiple different applications under this RFA; however,
substantially similar proposals may not be submitted to the two agencies.
 
PROGRAM DESCRIPTION
 
The SEPA Program will support grants designed to encourage scientists to work
with educators and community organizations to improve student and public
understanding of science, and increase interest of young people in scientific
careers.  The focus of student activities is to be at the kindergarten through
twelfth grade (K-12) level.  The scientists who study disease and illness and
those who carry out basic research relating to these disorders, have a major
contribution to make by conveying their knowledge and also the excitement in
doing research.  However, it is also essential that scientists work with
educators, school administrators, community leaders, the media, and others in
order to make effective contributions to improving science education and
improving public understanding of both the process and accomplishments of
science.
 
ADAMHA will support partnership projects that focus on any scientific area
relevant to the ADAMHA mission.  Hence, the focus of this award is on building
partnership programs.  ADAMHA is especially interested in projects that focus
on scientific knowledge about the brain and behavior and their relation to the
addictive and mental disorders.  This includes the basic sciences underlying
these disorders, such as the neurosciences, psychology, pharmacology,
genetics, and other relevant sciences.
 
The NIH SEPA Program will support the development of model programs that join
working scientists and educators in enhancing the precollege science education
and public understanding in such biomedical science areas as molecular
biology, molecular genetics, immunology, neuroscience, and bioinformatics, as
well as ethical issues, the benefits and risks of genetic engineering, and the
role of environmental health.
 
ADAMHA and NIH will consider cofunding of projects focussing on general
aspects of health science (e.g., the responsible use of animals in biomedical
and behavioral science or biotechnology) or scientific areas that cut across
the mission of both agencies (e.g., neurosciences, genetics, and health and
behavior).  A single application should be submitted for such projects.
 
The ADAMHA and the NIH encourage and support the initiation of cooperative
efforts among diverse elements in the scientific and education community,
 
            NIH GUIDE - Vol. 20, No. 5, February 1, 1991 - Page 19
including university scientists, elementary and secondary schools,
foundations, private industry, the media, and museums, to develop model
programs for increasing scientific literacy.  The ADAMHA/NIH SEPA Program
seeks to focus on the improvement of science education through partnerships
between public and private sector organizations and the working scientists.
Carefully crafted partnerships can create channels for transferring
information about new scientific discoveries, improve curricula, and develop
textbooks and other materials that increase and impart to students, teachers,
and the general public the utility of biomedical/behavioral research.  The
essential feature of the program is the active participation of scientists
with the scientific and technical knowledge and resources with the knowledge
and pedagogical expertise of educators.  Research institutions are encouraged
to provide, from non-Federal sources, incentives for their scientists to
participate in the SEPA Program.  These incentives may include the awarding of
sabbaticals, time released from other duties, or special institutional
recognition to individuals, to permit them to participate in the program.
Such applicants are also encouraged to use institutional funds released as a
result of the SEPA award (e.g., investigators' salaries) for purposes
consistent with this award.
 
ADAMHA and NIH seek the development of model projects and, therefore, priority
will be given to applications with the potential for widespread use and
replication.
 
MECHANISM OF SUPPORT/AVAILABILITY OF FUNDS
 
This RFA will use the grant-in-aid for education projects (R25).
Responsibility for the planning, direction, and execution of the proposed
project will be solely that of the applicant.  Except as otherwise stated in
this RFA, awards will be administered under PHS grants policy as stated in the
Public Health Service Grants Policy Statement.
 
This RFA is a one-time solicitation.  The ADAMHA and the NIH expect that $2
million will be available to each agency (a total of $4 million) during FY
1991 to support this initiative.  Subject to the availability of funds and
receipt of a sufficient number of meritorious applications, it is anticipated
that approximately ten to twenty projects will be supported.
 
Applicants may request support for up to three years.  Annual direct cost
requests for the proposed activities are expected to range from approximately
$100,000 to $250,000.  Indirect costs will be provided.  The anticipated award
date is September 30, 1991.
 
REVIEW PROCEDURES
 
Applications that are complete and responsive will be evaluated for
educational and scientific/technical merit by an appropriate peer review group
convened by ADAMHA and NIH.  Applications may be subjected to triage by a peer
review group to determine their educational and scientific merit relative to
other applications received in response to this RFA.  Those applications
judged to be competitive will undergo further merit review.  The second level
of review will be provided by the National Advisory Mental Health Council
and/or the National Advisory Research Resources Council.
 
METHOD OF APPLYING AND LETTER OF INTENT
 
The Application for Public Health Service Grant Form PHS-398 (revised 10/88)
must be used in applying for these grants.  These forms are available at most
institutional business offices and from the Office of Grants Inquiries,
Division of Research Grants, NIH, 5333 Westbard Avenue, Bethesda, Maryland
20892, (301) 496-7441.  Prospective applicants must request a copy of the
complete RFA, which includes supplemental instructions for completion of the
Form PHS-398, from the staff identified below (see INQUIRIES).
 
Prospective applicants are asked to submit, by March 15, 1991, a letter of
intent that includes a descriptive title of the proposed project; the name,
address, and telephone number of the Principal Investigator; the names of
other key personnel, the participating institutions; and the number and title
of the RFA in response to which the application is being submitted.
 
Although a letter of intent is not required, is not binding, and does not
enter into the review of subsequent applications, the information that it
contains is extremely helpful in planning for the review of applications.  It
allows staff to estimate the potential review workload and to avoid possible
conflict of interest in the review.
 
The ADAMHA letter of intent should be sent to the Deputy Director, Division of
Extramural Activities, National Institute of Mental Health, Parklawn Building
 
            NIH GUIDE - Vol. 20, No. 5, February 1, 1991 - Page 20
Room 9-105, 5600 Fishers Avenue, Rockville, MD 20857.  The NIH letter of
intent should be sent to Dr. Marjorie A. Tingle (see address below).  A copy
of the letter of intent should be addressed to:
 
Anthony Demsey, Ph.D.
Associate Director for Referral and Review
Division of Research Grants
National Institutes of Health
Westwood Building, Room 338
5333 Westbard Avenue
Bethesda, MD  20892**
 
INQUIRIES
 
Written or telephone inquiries regarding this RFA, and requests for the
complete RFA may be directed to either:
 
Dr. Joel W. Goldstein
ADAMHA SEPA Program
Room 13-103
5600 Fishers Lane
Rockville, MD  20857
Telephone:  (301) 443-9674
 
or
 
Marjorie A. Tingle, Ph.D.
NIH SEPA Program
National Center for Research Resources
Westwood Building, Room 10A11
5333 Westbard Avenue
Bethesda, MD  20892**
Telephone:  (301) 496-6743
 
ADAMHA awards are under the authority of Section 301 of the Public Health
Service Act, as amended, (42 U.S.C. 241).  NIH awards are under authorization
of the Public Health Service Act, Title IV, Part A (Public Law 78-410, as
amended by Public Law 99-158, 42 USC 241 and 285).  All awards will be
administered under PHS grant policies and Federal Regulations 42 CFR 52 and 45
CFR Parts 74 and 92.  This program is not subject to the intergovernmental
review requirements of Executive Order 12372 or Health Systems Agency review.

MULTICENTER COOPERATIVE AGREEMENT FOR STUDYING NEURAL TUBE DEFECTS IN MUTANT
MICE
 
RFA AVAILABLE:  HD-91-01
 
P.T. 34; K.W. 0710030, 1002004, 1002019, 1002059, 0755030
 
National Institute of Child Health and Human Development
 
Application Receipt Date:  April 22, 1991
 
OVERVIEW
 
Neural tube defects (NTDs) are among the most common congenital defects,
occurring at a rate of 1-2/1000 live births.  Despite their frequency the
causes of NTDs are still not understood.  The National Institute of Child
Health and Human Development (NICHD) invites research applications from
investigators willing to participate with NICHD assistance under cooperative
agreements in a multicenter cooperative program designed to investigate the
etiology of neural tube defects.  The objective of the study is to bring
together a multidisciplinary group of investigators to characterize mammalian
neurulation in a mouse genetic model for spina bifida, the curly tail mouse,
developed under NICHD contract.  Particular emphasis will be given to
individual studies examining the molecular, cellular, biophysical, and
morphological mechanisms involved in neural tube formation.  The cooperative
agreement mechanism has been chosen to facilitate identification of the
etiology of spina bifida by coordinating research among the individual sites
within the program.  Analyses of the various aspects of NTD formation will be
coordinated among the investigators, and it is anticipated that there will be
substantial evolution of the program as new findings are obtained and shared.
The benefit of such a cooperative venture will be to better define the
mechanisms by which normal neurulation occurs and to characterize the
processes leading to NTDs in a well defined mammalian model with an
applicability to the human condition.

            NIH GUIDE - Vol. 20, No. 5, February 1, 1991 - Page 21
MECHANISM OF SUPPORT
 
Support will be available through the cooperative agreement mechanism (U01)
between individual investigators and the NICHD.  The major difference between
a cooperative agreement and a research grant is that there will be substantial
programmatic involvement of NICHD staff above and beyond the levels required
for traditional program management of grants.
 
It is anticipated that four awards totaling $800,000 (direct costs) for the
first year will be made with an award period of five years.
 
REVIEW PROCEDURES
 
Applications will be reviewed by the NICHD staff for responsiveness to the
Request for Applications (RFA) and may receive a triage review for relative
scientific merit by a peer review group.  Scientific and technical merit will
be evaluated by a special review committee convened specifically for this
purpose by the Division of Scientific Review, NICHD.  A second-level review
will be done by the National Advisory Child Health and Human Development
Council.
 
APPLICATION PROCEDURE
 
Applications must be submitted on form PHS 398, Revised 10/88.
 
ADDITIONAL INFORMATION
 
Potential applicants are encouraged to request the detailed RFA by
telephoning:
 
Delbert Dayton, M.D.
Genetics and Teratology Branch
Center for Research for Mothers and Children
National Institute of Child Health and Human Development
Executive Plaza North, Room 643
9000 Rockville Pike
Bethesda, MD  20892
Telephone:  (301) 496-5541
 
The full RFA is also available on the electronic version of the NIH Guide for
Grants and Contracts, the E-Guide.

                                   ERRATUM

ADDENDUM:  NATIONAL INSTITUTE ON DRUG ABUSE - ANNOUNCEMENT AND GUIDELINES -
AUGUST 1990
 
PA:  PA-90-31
 
P.T. 34; K.W. 0404009, 1014006
 
National Institute on Drug Abuse
 
As an addendum to the National Institute on Drug Abuse (NIDA) Research Grants
Program Announcement and Guidelines, PA-90-31 (published in the NIH Guide for
Grants and Contracts, Vol. 19, No. 32, September 7, 1990, NIDA wishes to
include as part of Research Support Mechanisms the following:  (7) Program
Project Grants (P01).  Although the P01 mechanism was included in the
September 7, 1990, NIH Guide notice, the complete, printed copy of the
announcement inadvertently omitted it as one of the possible support mechanism
acceptable under this announcement.  Today's notice is to confirm that the P01
support mechanism is acceptable under announcement PA-90-31.  All other
aspects of the announcement remain unchanged.

**THE MAILING ADDRESS GIVEN FOR SENDING APPLICATIONS TO THE DIVISION OF
RESEARCH GRANTS OR CONTACTING PROGRAM STAFF IN THE WESTWOOD BUILDING IS THE
CENTRAL MAILING ADDRESS FOR THE NATIONAL INSTITUTES OF HEALTH.  APPLICANTS WHO
USE EXPRESS MAIL OR A COURIER SERVICE ARE ADVISED TO FOLLOW THE CARRIER'S
REQUIREMENTS FOR SHOWING A STREET ADDRESS.  THE ADDRESS FOR THE WESTWOOD
BUILDING IS:
 
5333 Westbard Avenue
Bethesda, Maryland 20816

 
            NIH GUIDE - Vol. 20, No. 5, February 1, 1991 - Page 22