Subject: (Copy) NIH GUIDE - Vol. 19, No. 21, June 8, 1990
From: Dot Baker <[email-masked]>
To: [email-masked]
Date: Thu, 07 Jun 90 14:48 EST

Hello Paul,
This is the first of two articles coming to you today for the NIH
Listserver.  Please post this one as: NIHGUIDE.060890.
    Thanks,
           Dottie
 ---------------------------- Text of forwarded message -----------------------
     
NIH GUIDE - Vol. 19, No. 21, June 8, 1990

                                   NOTICES

"OTHER SUPPORT" IN PHS GRANT APPLICATIONS ..............(84/110)............. 1
National Institutes of Health
Alcohol, Drug Abuse, and Mental Health Administration
Index:  NATIONAL INSTITUTES OF HEALTH
        ALCOHOL, DRUG ABUSE, AND MENTAL HEALTH ADMINISTRATION

"OTHER SUPPORT" IN NIH AND ADAMHA R&D CONTRACT PROPOSALS ...(113/133)........ 1
National Institutes of Health
Alcohol, Drug Abuse, and Mental Health Administration
Index:  NATIONAL INSTITUTES OF HEALTH
        ALCOHOL, DRUG ABUSE, AND MENTAL HEALTH ADMINISTRATION

PRIMATE TISSUE BANKING AND DISTRIBUTION PROGRAM ............(136/168)........ 1
National Center for Research Resources
Index:  RESEARCH RESOURCES

NIH WORKSHOP FOR ELECTRONIC TRANSMITTAL OF FINANCIAL STATUS REPORTS ......... 2
National Institutes of Health                               (171/199)
Index:  NATIONAL INSTITUTES OF HEALTH

                   NOTICES OF AVAILABILITY (RFPs AND RFAs)

CLARIFICATION:  DEVELOPING AND IMPROVING INSTITUTIONAL ANIMAL
RESOURCES (RFA RR-90-02) ...................................(205/234)........ 2
National Center for Research Resources
Index:  RESEARCH RESOURCES

PERINATAL EMPHASIS RESEARCH CENTERS (RFA HD-90-10) ...(241/303, 564/978).... 3
National Institute of Child Health and Human Development
Index:  CHILD HEALTH, HUMAN DEVELOPMENT

                        ONGOING PROGRAM ANNOUNCEMENTS

CHILDREN WITH HIV INFECTION AND AIDS (PA-90-15) ......(324/493).............. 4
National Institute of Mental Health
National Institute on Drug Abuse
National Institute on Child Health and Human Development
National Institute of Neurological Disorders and Stroke
National Center for Nursing Research
Index:  MENTAL HEALTH, DRUG ABUSE, CHILD HEALTH, HUMAN DEVELOPMENT,
        NEUROLOGICAL DISORDERS, STROKE, NURSING RESEARCH

     

     

     

     

     

     
     
                                   NOTICES

"OTHER SUPPORT" IN PHS GRANT APPLICATIONS
     
P.T. 34; K.W. 1014002, 1014006
     
National Institutes of Health
Alcohol, Drug Abuse, and Mental Health Administration
     
The PHS 398 (Rev. 10/88) and PHS 2590 (Rev. 10/88) grant application forms
include a section on OTHER SUPPORT, where applicants are expected to list all,
including both Federal and non-Federal, active support and pending and planned
requests for support of research and research-related activities by all key
personnel listed for each application.  This information is important to PHS
review-award processes to help evaluate the compatibility of application
requests with investigators' capabilities and responsibilities, and eliminate
unwarranted duplication of support for investigators' efforts.  Application
instructions emphasize the requirement for complete, accurate, and reliable
information.  In signing the face page of the application the principal
investigator/program director and the applicant institution official certify
that the application information is accurate and complete.
     
Applicants are reminded of the necessity to provide the full and reliable
information requested.  As noted in the instructions, "Incomplete, inaccurate,
or ambiguous information about OTHER SUPPORT could lead to delays in review of
the application."  Further, applicants should be cognizant that serious
consequences could result if failure to provide complete and accurate
information be construed as an attempt to mislead PHS agency advisory groups
and staff in their review and award responsibilities.

"OTHER SUPPORT' IN NIH AND ADAMHA R&D CONTRACT PROPOSALS
     
P.T. 34; K.W. 1014002, 1014006
     
National Institutes of Health
Alcohol, Drug Abuse, and Mental Health Administration
     
Documentation required in National Institutes of Health and Alcohol, Drug
Abuse, and Mental Health Administration uniform Request for Proposals
include Standard Form 1411, Contract Pricing Proposal Cover Sheet,
which instructs offerors to identify any contracts or subcontracts they have
been awarded "for the same or similar items" within the past three years.
Additionally, offerors are required to provide a Summary of Related
Activities, identifying all active federal contracts, cooperative agreements,
grants, and commercial agreements, and submitted proposals, including actual
and proposed levels of effort for all key individuals in the proposal to NIH.
     
As with PHS grant applications, mentioned just above, offerors should be aware
that serious consequences could result if their failure to provide complete
and accurate information be construed as an attempt to mislead agency advisory
groups and staff in their review and award responsibilities.

PRIMATE TISSUE BANKING AND DISTRIBUTION PROGRAM
     
P.T. 34; K.W. 0780005, 0780020
     
National Center for Research Resources
     
The Tissue Banking and Distribution Program at the University of Washington
Regional Primate Research Center provides tissue and fluid specimens from
macaques and baboons.  Viable specimens in culture media are prepared for
shipment in less than an hour and delivered to most laboratories in the U.S.
within 24 hours.  Delivery of quick-frozen or fixed specimens is made on a
scheduled basis.  More specialized preparations are supplied on request.  A
clinical, surgical and experimental history of the donor animal accompanies
each specimen.
     
The Tissue Banking and Distribution Program is partially supported by the
National Center for Research Resources, NIH.

     

     
     
              NIH GUIDE - Vol. 19, No. 21, June 8, 1990 - Page 1
For more information, call or write:
     
Mr. Whalen Kuller
Tissue Program Coordinator
Regional Primate Research Center, SJ-50
University of Washington
Seattle, WA  98195
Telephone:  (206) 543-6999

NIH WORKSHOP FOR ELECTRONIC TRANSMITTAL OF FINANCIAL STATUS REPORTS
     
P.T. 42; K.W. 1014006
     
National Institutes of Health
     
The Division of Financial Management, Grants Section, will conduct a two-day
workshop on "THE SYSTEM FOR ELECTRONIC TRANSMITTAL OF FINANCIAL STATUS
REPORTS" (FSR'S), July 26-27, 1990, to be held in Bethesda, Maryland.
     
The workshop will emphasize the use of computer technology in transmitting
FSR'S electronically and the benefits realized by both the NIH and grantee
organizations who are currently authorized users of this system.  A wide range
of topics relating to the development and the practicality of this system will
be discussed.  The workshop will include a hands-on demonstration which will
allow the participants to practice some of the knowledge gained by attending
this workshop.  Participants will be shown how to access the FSR system and
will practice submitting FSR'S electronically.
     
Other topics will include policy relating to the Expanded Authority and the
Federal Demonstration Project, networks and terminal emulators, Payment
Management System (PMS) Smartlink (payment request system) and the correlation
of the Federal Cash Transaction Report (PMS-272) and the FSR.
     
For additional information and registration forms, please call Priscilla Irick
or Tracy Wessinger on (301) 496-5287.
     
The number of participants for this workshop is limited.  Registration forms
must be returned to NIH no later than July 2, 1990.

                   NOTICES OF AVAILABILITY (RFPs AND RFAs)

CLARIFICATION:  DEVELOPING AND IMPROVING INSTITUTIONAL ANIMAL RESOURCES
     
RFA:  RR-90-02
     
P.T. 34; K.W. 0780000, 1002002
     
National Center for Research Resources
     
The National Center for Research Resources has recently announced a
competitive grant program, RFA RR-90-02, "Developing and Improving
Institutional Animal Resources," to assist institutions in upgrading their
research animal facilities.  The program, announced in the May 4, 1990 issue
of the NIH Guide for Grants and Contracts, Vol. 19, No. 18, is intended for,
but not restricted to, those institutions that receive more than $500,000 of
Public Health Service funds annually for animal-related research.  The total
award must be matched (dollar-for-dollar) by non-federal funds.  A second
program, intended for those institutions that receive less than $500,000 of
Public Health Service funds annually for animal-related research, will be
announced later in calendar year 1990.  No matching funds will be required
under the second program.  An institution that is eligible for the second
program is also eligible for the first program but can only apply to one
program, not both.
     
Inquiries regarding these programs may be directed to:
     
Animal Resources Program
National Center for Research Resources
5333 Westbard Avenue, Room 857
Bethesda, MD  20892
Telephone:  (301) 496-5175

     

              NIH GUIDE - Vol. 19, No. 21, June 8, 1990 - Page 2
PERINATAL EMPHASIS RESEARCH CENTERS
     
RFA AVAILABLE:  HD-90-10
     
P.T. 04; K.W. 0775020, 0775025, 0403020, 0775015, 0411005, 0710030
     
National Institute of Child Health and Human Development
     
Letter of Intent Receipt Date:  July 20, 1990
Application Receipt Date:  September 19, 1990
     
PURPOSE
     
The National Institute of Child Health and Human Development (NICHD) invites
applications from current members of the Perinatal Emphasis Research Center
(PERC) program (competitive continuation applications) and from prospective
members (new applications) with the objective of encouraging investigators to
develop multidisciplinary research efforts that will advance knowledge about
diseases and disorders of pregnancy and infancy.  These grants are for the
support of hypothesis-testing research efforts; they are not intended to
support service, survey, or demonstration projects.  PERCs are organized
around problem/need themes and are established where research can be
coordinated with existing programs of health care to ensure the rapid
assimilation of new scientific knowledge into health care delivery.  Active
PERCs are addressing issues in high-risk pregnancies (diabetes, hypertension),
prevention of prematurity, fetal hypoxia, and intrauterine growth retardation.
     
Inclusion of women and minorities in study populations:  Investigators should
be aware that NIH urges applicants to give added attention, where feasible and
appropriate, to the inclusion of minorities and women in study populations.
If minorities and/or women are not included in a given study, a clear
rationale for their exclusion should be provided.  Merely including an
arbitrary number of minority group and women participants in a given study is
insufficient to guarantee generalization of results.
     
MECHANISM OF SUPPORT
     
The support mechanism of these programs is the specialized P-50 Perinatal
Emphasis Research Centers Grants.  The P-50 grants differ from program project
grants in that P-50s usually are developed in response to an announcement of
the programmatic needs of an institute or division and subsequently receive
continuous attention from its staff.  Although this solicitation is included
in the plans for FY 1991, support for these center grants is contingent upon
the receipt of funds for this purpose.  Policies that govern grant-in-aid
award programs of the Public Health Service will prevail.  The number of
grants to be awarded is also contingent upon a sufficient number of
applications receiving a high level of merit to be considered for an award.
It is expected that up to four (4) awards will be made as the result of this
announcement.
     
APPLICATION PROCEDURE - Applications must be submitted on form PHS 398
(revised 10/88).
     
ADDITIONAL INFORMATION - Potential applicants are encouraged to request a
detailed request for application by contacting:
     
Charlotte S. Catz, M.D., Chief
Pregnancy and Perinatology Branch, CRMC
NICHD, NIH
Executive Plaza North, Room 643
9000 Rockville Pike
Bethesda, MD  20892
Telephone:  (301) 496-5575

     

     

     

     

     
     
              NIH GUIDE - Vol. 19, No. 21, June 8, 1990 - Page 3
                        ONGOING PROGRAM ANNOUNCEMENTS

CHILDREN WITH HIV INFECTION AND AIDS
     
PA:  PA-90-15
     
P.T. 34, AA; K.W. 0715008, 0770005, 0705055, 0745020, 0730050, 0404000
     
National Institute of Mental Health
National Institute on Drug Abuse
National Institute on Child Health and Human Development
National Institute of Neurological Disorders and Stroke
National Center for Nursing Research
     
PURPOSE
     
Children are among the growing number of persons who are infected with the
Human Immunodeficiency Virus (HIV).  AIDS is the ninth leading cause of death
among children between the ages of one and four years old.  It is estimated
that by 1991, one out of ten pediatric hospital beds will be occupied by a
child with AIDS.
     
HIV infection and AIDS in infants and children differs from the disease in
adult in major ways.  Because they have not reached developmental maturity,
infants and children may experience poor growth and mental and motor
dysfunction.  They experience more bacterial infection and pulmonary diseases
than adults, requiring longer hospitalizations and more outpatient management.
Infants and children seem to be less susceptible to opportunistic infections
of the CNS.  Infants and children are also dependent on a caregiver for
treatment.
     
RESEARCH OBJECTIVES
     
Institutes in the Public Health Service (PHS) already have active program
announcements addressing HIV infection and AIDS, but this program announcement
is intended to highlight specific areas with respect to infants and children
with HIV infection and AIDS and their families and caregivers.  The areas of
research could include but are not limited to:
     
  o  Central Nervous System Effects of Human Immunodeficiency Virus
     Infection in Infants
     
  o  Brain, Immune System, and Neurological Aspects of HIV
     
  o  Accurate Methods of Diagnosis and Assessment of Neurologic and
     Neuropsychological Abnormalities and Dysfunction
     
  o  Neurobehavioral, Psychiatric, and Psychosocial Issues
     
  o  Prevalence of Developmental and Mental Disorders Associated with
     HIV Infection and AIDS
     
  o  Nature and Course of HIV-Related Mental Disorders
     
  o  Mental Health Services for Children/Families Affected by HIV
     
  o  Research on Behavior Change and Prevention Strategies with Infants
     and Children and Adults
     
MECHANISMS OF SUPPORT
     
Support for applications submitted in response to this announcement will be
through grants for individual research projects, First Independent Research
Support and Transition (FIRST) awards.
     
ELIGIBILITY
     
Applications may be submitted by public, private nonprofit, or for-profit
institutions such as universities, colleges, hospitals, laboratories, units of
State or local government, and eligible agencies of the Federal Government.
Women and minority investigators are encouraged to apply.
     
INCLUSION OF MINORITIES IN STUDY POPULATIONS
     
PHS urges applicants to give added attention (where feasible and appropriate)
to the inclusion of minorities in study populations for research into the
etiology of disease, research in behavioral and social sciences, clinical
     
              NIH GUIDE - Vol. 19, No. 21, June 8, 1990 - Page 4
studies of treatment and treatment outcomes, research on the dynamics of
health care and its impact on disease, and appropriate interventions for
disease prevention and health promotion.  If minorities are not included in a
given study, a clear rationale for their exclusion should be provided.
     
INCLUSION OF FEMALES IN STUDY POPULATIONS
     
PHS urges applicants to consider the inclusion of females in the study of
populations for all clinical research efforts.  Where studies involve pregnant
women, special care needs to be taken so that the fetus is not exposed to
undue risks.  Gender differences should be noted and evaluated.
     
RECEIPT AND REVIEW SCHEDULE
     
The deadlines for receipt of applications are January 2, May 1, and September
1.  Assignment to PHS Insitutes will be based on established guidelines.  The
initial review for scientific and technical merit will be by an appropriate
initial review group, and secondary review will be by an advisory council.
     
REVIEW CRITERIA
     
The main criteria for scientific/technical merit review of applications are:
scientific significance of the research goals and adequacy of theoretical
framework; scientific merit of research design and methodology; adequacy of
data analysis plan; qualifications of the principal investigator and staff;
appropriateness of budget estimate for proposed research activities; and
protection for human and animal subjects.
     
AWARD CRITERIA
     
Funding decisions will be based upon relative scientific merit, program
relevance, and the availability of funds.
     
APPLICATION PROCEDURES
     
Complete line 2 of the application face page (PHS 398) by inserting the title
and number of this program announcement, "CHILDREN WITH HIV INFECTION AND
AIDS, PA-90-15," and check the YES box.
     
Applicants will be responsible for submitting the signed original grant
application form, PHS 398 (Rev.  10/88) and 24 legible copies (6 copies of
appendix material) to:
     
Division of Research Grants, NIH
Westwood Building, Room 240
Bethesda, MD  20892**
     
ADDITIONAL INFORMATION:
     
Please contact one of the following persons for additional information:
     
Ellen Stover, Ph.D.
Director, Office of AIDS Programs
National Institute of Mental Health
5600 Fishers Lane, 17C06
Rockville, MD  20857
Telephone:  (301) 443-7281
     
Harry Haverkos, M.D.
Acting Director
Division of Clinical Research
National Institute on Drug Abuse
Parklawn Building, 10A-08
Rockville, MD  20857
Telephone:  (301) 443-1801
     
Anne Willoughby, M.D.
Chief, Pediatric, Adolescent and Maternal AIDS Branch
National Institute of Child Health and Human Development
6130 Executive Boulevard
Bethesda, MD  20892
Telephone:  (301) 496-7339

     

     
     
              NIH GUIDE - Vol. 19, No. 21, June 8, 1990 - Page 5
A. P. Kerza-Kwiatecki, Ph.D.
Health Scientist Administrator
Div. of Demyelinating, Atropic, and Dementing Disorders
National Institute on Neurological Disorders and Stroke
7550 Wisconsin Avenue
Bethesda, MD  20892
Telephone:  (301) 496-5679
     
Janet Heinrich, Dr. PH; R.N.
Director, Division of Extramural Programs
National Center for Nursing Research
Bethesda, MD  20892
Telephone:  (301) 496-0523

**THE MAILING ADDRESS GIVEN FOR SENDING APPLICATIONS TO THE DIVISION OF
RESEARCH GRANTS OR CONTACTING PROGRAM STAFF IN THE WESTWOOD BUILDING IS THE
CENTRAL MAILING ADDRESS FOR THE NATIONAL INSTITUTES OF HEALTH.  APPLICANTS WHO
USE EXPRESS MAIL OR A COURIER SERVICE ARE ADVISED TO FOLLOW THE CARRIER'S
REQUIREMENTS FOR SHOWING A STREET ADDRESS.  THE ADDRESS FOR THE WESTWOOD
BUILDING IS:
     
5333 Westbard Avenue
Bethesda, Maryland 20816

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     
     
              NIH GUIDE - Vol. 19, No. 21, June 8, 1990 - Page 6