Subject: l0/5/90 NIH Guide.
From: Dot Baker <[email-masked]>
To: [email-masked]
Date: Wed, 03 Oct 90 15:44 EST

Hello,
   This is the third and last for the day.  Please post to the
NIH Listserver as:
   NIHGUIDE.100590
 ---------------------------- Text of forwarded message -----------------------
 
X-comment: NIH Guide (including TOC) contained 10 pages (800 lines)
X-comment: RFAs described:  CA-91-02, CA-91-01

 

 
NIH GUIDE - Vol. 19, No. 36, October 5, 1990

                                   NOTICES

FISCAL YEAR 1991 BUDGET ISSUES ......................(84/119)............... 1
National Institutes of Health
Alcohol, Drug Abuse, and Mental Health Administration
Index:  NATIONAL INSTITUTES OF HEALTH
        ALCOHOL, DRUG ABUSE, AND MENTAL HEALTH ADMINISTRATION

NEW NIH/ADAMHA PEER REVIEW CONSULTANT FILE ..........(122/150).............. 1
National Institutes of Health
Alcohol, Drug Abuse, and Mental Health Administration
Index:  NATIONAL INSTITUTES OF HEALTH
        ALCOHOL, DRUG ABUSE, AND MENTAL HEALTH ADMINISTRATION

THANK YOU TO PHS 398 RESPONDENTS ....................(161/174).............. 2
Division of Research Grants
Index:  DIVISION OF RESEARCH GRANTS

E-GUIDE ACCESS - REPORT OF THE MEETING ..............(177/252).............. 2
National Institutes of Health
Index:  NATIONAL INSTITUTES OF HEALTH

                   NOTICES OF AVAILABILITY (RFPs AND RFAs)

DEVELOPMENT OF NOVEL DRUG FORMULATION AND DELIVERY SYSTEMS FOR
ANTI-TUMOR AND ANTI-AIDS AGENTS (RFP) ...............(258/311).............. 3
National Cancer Institute
Index:  CANCER

CLINICAL CENTERS FOR A CHILDHOOD ASTHMA MANAGEMENT PROGRAM (RFP) ........... 4
National Heart, Lung, and Blood Institute            (321/367)
Index:  HEART, LUNG, BLOOD

EPIDEMIOLOGY OF CANCER IN U.S. ETHNIC/MINORITY POPULATIONS (RFA CA-91-02) .. 4
National Cancer Institute                            (370/457, 804/1080)
Index:  CANCER

AIDS-LYMPHOMA NETWORK (RFA CA-91-01) ................(460/591, 1083/1557)... 5
National Cancer Institute
Index:  CANCER

                        ONGOING PROGRAM ANNOUNCEMENTS

STROKE IN BLACKS, OTHER MINORITIES, AND WOMEN (PA-91-01) ..(597/733)........ 7
National Institute of Neurological Disorders and Stroke
Index:  NEUROLOGICAL DISORDERS AND STROKE

 

 

 

 

                                   NOTICES

FISCAL YEAR 1991 BUDGET ISSUES
 
P.T. 34; K.W. 1014006
 
National Institutes of Health
Alcohol, Drug Abuse, and Mental Health Administration
 
The purpose of this notice is to provide the National Institutes of Health
(NIH) and the Alcohol, Drug Abuse, and Mental Health Administration (ADAMHA)
research grantees and contractors with information on the potential impact of
the Gramm-Rudman-Hollings (GRH) Act on the Fiscal Year (FY) 1991 budget and
associated grant and contract funding.
 
The GRH Act requires that appropriations for each fiscal year be consistent
with the need to reduce the national budget deficit to a predetermined amount.
If actions on the appropriation do not satisfy the requirements of the GRH
Act, a process called "sequestration" automatically begins.  This process
results in mandatory across-the-board spending reductions for Federal
agencies.
 
There are several key dates in the sequestration process.  An initial
sequester order was issued on August 25 and specified a spending cut of 32.4
percent between October 1 and 15.  A final sequester order must be issued on
October 15 to specify the spending cuts required from October 15, 1990,
through September 30, 1991.  These sequester orders will be cancelled, or
become unnecessary, if the Congress passes--and the President signs--
legislation that meets the deficit reduction requirements.
 
All Federal agencies are now faced with the necessity of developing
contingency plans in the event that these sequesters do occur.  What this
means, in more specific terms, is that some restrictions on Federal spending
may be imposed, and most agencies will be required to reduce their costs for
numerous activities including grants and contracts.
 
As further details regarding operating budgets for FY 1991 are obtained, the
NIH and ADAMHA will broadly disseminate them to the scientific community.

NEW NIH/ADAMHA PEER REVIEW CONSULTANT FILE
 
P.T. 34; K.W. 1014002
 
National Institutes of Health
Alcohol, Drug Abuse, and Mental Health Administration
 
The National Institutes of Health (NIH) and the Alcohol, Drug Abuse, and
Mental Health Administration (ADAMHA) have established a new consultant file
of peer reviewers.  Reviewers will be selected from a national pool of
scientists who are engaged in basic or applied research.  Data from qualified
respondents will be entered into a new computerized NIH/ADAMHA data base.
This unique data base will be used as one source from which candidates for
membership on NIH/ADAMHA committees and for other peer review activities are
drawn.  All qualified scientists are requested to participate.  Qualified
women and minority scientists are encouraged to apply.
 
A Consultant File Information Form has been sent to every PHS grantee and the
solicitation announcement will appear in major journals.  Other scientists who
are interested in participating should respond by letter requesting a copy of
the NIH/ADAMHA Consultant File Information Form.  Since the new file will be
established based solely on positive responses, your response is needed even
if you are already a consultant or are a member of a Reviewer's Reserve.  This
file is independent of other consultant files.  Your request should be sent
to:
 
NIH/ADAMHA Consultant File
4733 Bethesda Avenue, Suite 725, Dept. 02
Bethesda, MD  20814

 

 

 
            NIH GUIDE - Vol. 19, No. 36, October 5, 1990 - Page 1
THANK YOU TO PHS 398 RESPONDENTS
 
P.T. 34; K.W. 1014002
 
Division of Research Grants
 
The staff of the Public Health Service would like to thank the many
individuals who responded to the March 30 and April 27, 1990 NIH Guide
Announcements inviting comments and suggestions to improve the Public Health
Service Grant Application Kit (Form 398).  The response from the scientific
community was substantial and many useful and constructive comments were
received.  These comments have been carefully analyzed and many are being
incorporated into the new version of the Form PHS 398 which should be
available in late 1991.

E-GUIDE ACCESS - REPORT OF THE MEETING
 
P.T. 16; K.W. 1014002
 
National Institutes of Health
 
On September 7, nearly one hundred people from institutions located across the
United States and Canada attended a meeting concerning the electronic version
of the NIH Guide for Grants and Contracts (E-Guide).  Attendees had a wide
range of technical and administrative backgrounds and came from academic and
medical institutions, large and small.  The meeting was intended to bring
people together for information exchange about receiving and dealing with the
E-Guide, as well as to identify changes that should be made in its format
which would maximize its usefulness to users.  It included didactic
presentations, discussion, and on-line demonstrations.
 
Hope was expressed at the meeting that the E-Guide could be developed to the
point that it is truly an electronic document, rather than an electronic
version of a paper document.  Efforts will be dedicated toward accomplishing
this goal but may be limited by the extent to which the NIH can provide
financial resources.  Attendees expressed the desire that the electronic
format as transmitted by the NIH be kept simple, with most of the manipulation
performed at the receiver end.
 
There seemed to be consensus that unobtrusive delimiters for individual items
and the various sections of the Guide would be useful if they did not
interfere with clarity.  A test of such delimiters will be enacted in the near
future.  In addition, some attendees asked that standards be developed and a
manual be provided that describes the standards and other relevant
characteristics of the files so that institutional users can maximize their
use.  This is a point that will be considered for future implementation.
 
Institutions use a variety of approaches for local distribution, the list
server being a popular one that seems likely to see expanded use.
Considerable interest was expressed in the distribution systems and software
that were demonstrated by representatives from the University of California at
San Francisco, Johns Hopkins University, and the University of North Carolina.
Attendees felt that the publication of an up-to-date list of designated
institutional recipients of the E-Guide would facilitate inter- and
intra-institutional communication, including the exchange of ideas and
information on methods of internal distribution.
 
Questions arose as to the length of time that individual issues of the E-Guide
should be retained.  Key policy announcements are republished approximately
every six months, and most requests for applications or for proposals have a
specific receipt date, but some program announcements might be effective for a
very long time.  Back E-Guide issues probably always will be attainable from
the NIH in electronic and/or hard copy.  Nevertheless, archival maintenance
should receive additional attention, policy development, and implementation.
 
Comments also illustrated the need for tutorials in the use of the E-Guide, as
well as identification of approaches to help faculty and staff to use the
electronic format effectively and frequently.  In order to be fully
successful, the E-Guide must offer advantages that do not exist for the paper
version.  The potential for such advantages exists but further development is
necessary before it can be fully realized.
 
Attendees generally found the meeting to be very useful, and most felt that it
should be held again, perhaps on a regional basis or in conjunction with other
meetings, or with better and larger facilities so that several individuals can
attend from a single institution for better coordination in use of the
E-Guide.
 
            NIH GUIDE - Vol. 19, No. 36, October 5, 1990 - Page 2
Three handouts were made available at the meeting:  (1) "Using the NIH Guide
List Server Archives," (2) "Indexes to the NIH Guide for Grants and
Contracts," and (3) "Electronic Transmission of NIH Extramural Program
Information, Two Principal Modes of Operation."  They can be obtained from:
 
Ms. Claire Blados
Institutional Liaison Office
Building 31, Room 5B31
National Institutes of Health
Bethesda, MD  20892
Telephone:  (301) 496-5366
BITNET:  Q2C@NIHCU

                   NOTICES OF AVAILABILITY (RFPs AND RFAs)

DEVELOPMENT OF NOVEL DRUG FORMULATION AND DELIVERY SYSTEMS FOR ANTI-TUMOR AND
ANTI-AIDS AGENTS
 
RFP AVAILABLE:  NCI-CM-17527-49
 
P.T. 34; K.W. 0715008, 0715035, 0740020
 
National Cancer Institute
 
The National Cancer Institute (NCI), Division of Cancer Treatment,
Developmental Therapeutics Program, Pharmaceutical Resources Branch, is
interested in receiving proposals from organizations that have innovative
research ideas concerning improving intravenous delivery and other routes of
administration of chemotherapeutic agents.  A workload-per-year of 1-2
compounds having diverse chemical structures of either natural or synthetic
origin is anticipated.  The contractor's studies will be directed towards
resolving specific deliverability and/or stability problem(s) culminating in
an acceptable dosage form prepared on laboratory scale.  The contractor will
deliver to the NCI, small quantities (less than 50 units) of the
experimentally formulated products for preliminary evaluation for efficacy and
toxicity in rodents.
 
The Principal Investigator should possess a Ph.D. in chemistry, pharmacy, or a
related discipline, and have extensive experience with the development of
novel drug delivery systems.  The contractor should be experienced with drug
analysis procedures including UV, NMR and infrared spectroscopy, plus the
development of stability indicating assays using high performance liquid
chromatography (HPLC).
 
The contractor should have access to the necessary analytical equipment to
perform the required work, including animal facilities for biologic
evaluation.
 
This procurement is unrestricted.  The Standard Industrial Classification
(SIC) code is 8731.
 
This RFP will be available on or about October 23, 1990, and will be due
approximately seven (7) weeks thereafter.  It is anticipated that two (2)
cost-reimbursement, incrementally funded type contracts for a period of three
(3) years each, beginning approximately June 1991, will be awarded.  Requests
for the solicitation should reference the RFP number and be sent to the
address below.  No collect calls will be accepted.
 
Requests for this RFP should be addressed to:
 
Ms. Sandra A. Lehner, Contracts Specialist
National Cancer Institute
Research Contracts Branch
Treatment Contracts Section
Executive Plaza South, Room 602
National Institutes of Health
9000 Rockville Pike
Bethesda, MD  20892
Telephone:  (301) 496-8620

 

 

            NIH GUIDE - Vol. 19, No. 36, October 5, 1990 - Page 3
CLINICAL CENTERS FOR A CHILDHOOD ASTHMA MANAGEMENT PROGRAM
 
RFP AVAILABLE:  NHLBI-HR-90-13
 
P.T. 34, AA, FF; K.W. 0715013, 0715026, 0785035
 
National Heart, Lung, and Blood Institute
 
The purpose of this solicitation is to establish clinical centers for a
collaborative study of a Childhood Asthma Management Program (CAMP).  The
objective of this program is to determine, in a population of 5-9 year old
children with asthma, if regular use of either of two types of
antiinflammatory medications (inhaled corticosteroids or cromolyn sodium),
compared to regular bronchodilator medication and to each other, results in
greater lung function and less bronchial hyperresponsiveness over a five-year
period.  The program will require a clinical coordinating center (CCC) to
collect data from approximately 8 participating clinical centers, each
studying a minimum of 132 children with asthma aged 5-9 years, including 44
from minority groups, e.g., Blacks, Hispanics and Native Americans, over a 6
1/2-year period.  The clinical centers will be responsible for:  1)
participating in the development and preparation of the study protocol,
reporting forms, and manual of operations; 2) training staff to conduct the
study as outlined in an approved study protocol and manual of operations; 3)
during an 18-month period recruit 132 children (of both sexes) with asthma
aged 5-9 years, including 44 from minority groups, e.g., Blacks, Hispanics,
and Native Americans; 4) performing follow-up assessment of the subjects in
the manner specified in an approved manual of operations; 5) collecting and
forwarding subject data to the CCC; 6) interacting with the CCC to provide
data and information necessary for data analysis; and 7) working with other
study investigators in the preparation and writing of reports and manuscripts
for publication.
 
This announcement is for clinical centers only, and the Institute expects to
make 8 awards.  A separate Request for Proposals (RFP) for the coordinating
center will appear later.
 
This announcement is not an RFP.  It is anticipated that RFP NHLBI-HR-90-13
will be available on or about October 1, 1990, with proposals due on February
28, 1991.  Copies of the RFP may be obtained by submitting a written request
along with three (3) self-addressed mailing labels to the address identified
below.
 
Pamela S. Randall
Contracts Operations Branch, DEA
Westwood Building, Room 654, 5333 Westbard Avenue
National Heart, Lung, and Blood Institute
Bethesda, MD  20892

EPIDEMIOLOGY OF CANCER IN U.S. ETHNIC/MINORITY POPULATIONS
 
RFA AVAILABLE:  CA-91-02
 
P.T. 34, FF; K.W. 0715035, 0785055, 1002019, 0411005
 
National Cancer Institute
 
Application Receipt Date:  February 15, 1991
 
INTRODUCTION
 
The Division of Cancer Etiology of the National Cancer Institute invites grant
applications for epidemiologic studies of possible causes of cancer in U.S.
ethnic/minority populations.
 
RESEARCH GOALS AND SCOPE
 
The purpose of this Request for Applications (RFA) is to stimulate analytical,
site-specific studies of cancer etiology in ethnic/minority populations of the
United States.  Research strategies may involve cohort, case-control, or
genetic epidemiology designs as well as laboratory methodology.  Innovative
approaches that involve new inter-disciplinary collaboration, or include the
application of diagnostic or exposure measurements, are particularly
encouraged.  Whenever possible, studies should make cost-efficient use of
existing resources such as population-based cancer registries or specimen
repositories.  Emphasis should be placed on etiologic studies of the more
common cancers affecting the U.S. population, or on cancer sites with rising

            NIH GUIDE - Vol. 19, No. 36, October 5, 1990 - Page 4
incidence rates.  Projects will be evaluated on their potential for impact on
the overall understanding of cancer etiology and means of prevention.
 
The initiative permits a wide range of epidemiologic investigations of cancer
in U.S. ethnic/minority populations including, but not limited to, the
following:
 
  o  Cross-cultural studies of cancers with striking ethnic disparities
     in incidence rates, among groups residing in the same or different
     geographic areas, to identify more specifically the etiologic
     factors, and to study their relationship with biomarkers of
     exposure.
 
  o  Analytic studies of specific cancer sites to determine the impact
     of age-specific changes in exposures over time, due to waves of
     migration within the U.S. as well as from other countries, and/or
     to secular changes in lifestyle, occupation, and environment.
 
  o  Studies among Hispanics with special consideration given to the
     subgroups within the population.
 
  o  Studies of ethnic differences in the histologic and cytologic
     parameters of particular cancers that may reflect differences in
     exposures or susceptibility.
 
  o  Meta-analysis of previous studies to further refine known
     associations or yield new information on risk factors.
 
  o  Studies addressing methodological issues related to the
     heterogeneity of ethnic groups, especially dietary and genetic
     parameters.
 
  o  Molecular epidemiologic studies exploring differences in genetic
     predisposition to cancer due to variations in carcinogen
     metabolism, DNA repair activities, response to tumor promoters,
     measures of immune function, chromosome sensitivity to mutagens, or
     other factors.
 
  o  Genetic epidemiologic studies of polymorphisms associated with
     ethnic differences in cancer risk.
 
In any studies involving human subjects, where feasible and appropriate, women
should be included in the study population; otherwise a clear rationale for
their exclusion must be provided in the application.  Minority institutions
are encouraged to apply, and other institutions are encouraged to establish
collaborative arrangements with minority institutions.
 
Copies of the RFA may be obtained from:
 
Dr. A. R. Patel
Extramural Programs Branch
Epidemiology and Biostatistics Program
Division of Cancer Etiology
National Cancer Institute
Executive Plaza North, Suite 535
Rockville, MD  20892
Telephone:  (301) 496-9600

AIDS-LYMPHOMA NETWORK
 
RFA AVAILABLE:  CA-91-01
 
P.T. 34; K.W. 0715008, 0715035, 0755015
 
National Cancer Institute
 
Application Receipt Date:  January 16, 1991
 
The Division of Cancer Treatment (DCT) of the National Cancer Institute (NCI)
invites applications (R01 mechanism) from interested investigators to
participate in an AIDS-Lymphoma Network.  The AIDS-Lymphoma Network will be
composed of those institutions who successfully compete for funding in this
Request for Applications (RFA) to perform new therapeutic AIDS-lymphoma
clinical trials, or AIDS-lymphoma clinical trials with correlative laboratory
studies.  The purpose of the AIDS-Lymphoma Network is to foster interchange
among different institutions and to coordinate activities of the different
institutions working towards a common goal.
 
            NIH GUIDE - Vol. 19, No. 36, October 5, 1990 - Page 5
BACKGROUND
 
Adult and pediatric acquired immunodeficiency syndrome (AIDS) patients are
surviving longer due to improved retroviral and opportunistic infection
treatment and care.  As a result, acquired immunodeficiency
syndrome-associated malignancies have become more prevalent and are now a
major concern.  Lymphomas and Kaposi sarcomas are the malignancies most
frequently seen in AIDS patients.  Both non-Hodgkin's lymphoma (NHL) and
Hodgkin's disease (HD) have been described in these patients.  The etiology of
NHL in AIDS patients remains unclear.  The most prominent clinical features of
NHL in HIV-positive patients are the aggressive nature and course of the
disease and the presence of unusual extralymphatic disease in sites such as
the CNS or bowel.  Results of treatment using standard intensive multi-agent
chemotherapy have been disappointing, with median survival of less than one
year in treated patients, and difficult because conventional aggressive
combination chemotherapy exacerbates the patient's immunodeficient state.  The
choice of therapy must be based on the nature of the disease and the overall
condition of the patient.  The precise relationship of HD to the underlying
immunodeficient state in patients with HIV infection also remains unclear.
Clinical observations suggest that HD in this setting may have a different
natural history and therapeutic outcome when compared with HD in the general
population.  Patients with HIV infection and HD are likely to have a poor
therapeutic outcome and to develop AIDS-associated opportunistic infections
during therapy.
 
The NCI recognizes that research in AIDS-lymphoma is technically difficult to
conduct because of the complexity of this disease and the relatively limited
availability of study subjects at any single institution.  Thus it is
encouraging conduct of research relevant to this RFA in the context of an
AIDS-Lymphoma Network.  The AIDS-Lymphoma Network will serve as a resource of
information and will work to facilitate patient accrual, obtaining tissue
samples, and exchange of information and materials between involved
investigators.
 
RESEARCH GOALS AND SCOPE
 
The major goal of this RFA is to develop more effective management and
therapies for AIDS-lymphoma.  This goal can be accomplished by supporting (1)
the development of AIDS-lymphoma therapeutic clinical trials or (2)
AIDS-lymphoma clinical trials with correlative laboratory studies.
 
Both adult and pediatric AIDS-lymphoma studies involving non-Hodgkin's and
Hodgkin's disease are encouraged.  The therapeutic clinical trials (pilot,
phase I, or phase II) will usually involve a patient population ranging
between 5-40 patients with survival, response, and/or quality of life end
points.  NCI does not envision the establishment of multi-institutional
collaborative therapeutic clinical trials by the AIDS-Lymphoma Network at this
time.  Some examples of potential correlative laboratory studies could deal
with the following:  (1) What is the clinical significance of the abnormal
patterns of distribution of disease sites?  (2) What factors are involved in
the different clinical responses observed in AIDS-lymphomas?  (3) What are the
potentially exploitable features with respect to etiology and pathogenesis of
AIDS-lymphoma?  (4) What is the clinical significance of the molecular and
cytogenetic alterations specifically associated with AIDS-lymphoma?  (5) What
alterations occur in growth factors or oncogenes in AIDS-lymphoma patients
that may potentially lead to new therapies?  Investigators are not limited to
the above categories of potential studies.  Other scientific approaches may be
proposed.
 
MECHANISM OF SUPPORT
 
This RFA will use the NIH grant-in-aid R01 mechanism.  Approximately
$3,000,000 in total costs per year for three years will be committed to
specifically fund applications that are submitted in response to this RFA.  It
is anticipated that 10 to 15 awards will be made.  This funding level is
dependent on the receipt of a sufficient number of applications of high
scientific merit.  The earliest feasible start date for the initial award will
be July 16, 1991.  Although this program is provided for in the financial
plans of the NCI, the award of grants pursuant to this RFA is contingent upon
the availability of funds appropriated for fiscal year 1991.
 
ELIGIBILITY REQUIREMENTS
 
Applicant organizations should be located in the United States and Canada.
Non-profit and for-profit organizations and institutions, and government
agencies are eligible to apply.

 
            NIH GUIDE - Vol. 19, No. 36, October 5, 1990 - Page 6
LETTER OF INTENT
 
Prospective applicants are asked to submit by December 16, 1990, a letter of
intent that includes a descriptive title of the proposed research, the name
and address of the principal investigator, the names of other key personnel,
the participating institutions, and the number and title of this RFA.  The
letter of intent is requested in order to provide an indication of the number
and scope of applications to be reviewed.  This letter of intent does not
commit the sender to submit an application, nor is it a requirement for
submission of an application.
 
INQUIRIES
 
A copy of the complete RFA describing the research goals and scope, the review
criteria and the method of applying can be obtained by contacting:
 
Dr. Roy S. Wu
Health Scientist Administrator
Cancer Therapy Evaluation Program
Division of Cancer Treatment
National Cancer Institute
Executive Plaza North, Room 734
Bethesda, MD  20892
Telephone:  (301) 496-8866
FAX:  (301) 496-9384
 
Written or telephone inquiries concerning the objectives and scope of this RFA
or inquiries about whether or not specific proposed research would be
responsive are encouraged and should be directed to Dr. Roy S. Wu at the above
address.  The program director welcomes the opportunity to clarify any issues
or questions from potential applicants.

                        ONGOING PROGRAM ANNOUNCEMENTS

STROKE IN BLACKS, OTHER MINORITIES, AND WOMEN
 
PA:  PA-91-01
 
P.T. 34, FF, II; K.W. 0715200, 0785055, 0745020, 0745070, 0745027, 0411005
 
National Institute of Neurological Disorders and Stroke
 
The Division of Stroke and Trauma (DST), National Institute of Neurological
Disorders and Stroke (NINDS), invites applications for support of research
that will increase our knowledge and understanding of cerebrovascular disease
in blacks, other minorities, and women.
 
BACKGROUND
 
The Report of the Secretary's Task Force on Black and Minority Health
discusses the continuing disparity in the burden of death and illness
experienced by blacks and other minority Americans compared with the
population as a whole.  In the United States, stroke remains a leading cause
of death and a prime cause of disability.  Nearly half a million Americans
each year are known to suffer an acute stroke.  The overall problem is even
more imposing than annual incidence and mortality figures would indicate,
since many strokes are not fatal and recurrent strokes are common in nearly
all forms of cerebrovascular disease.  Additionally, many transient attacks
(TIA) and minor strokes frequently remain unreported.  In the black
population, age-adjusted death rates for stroke are almost twice that of the
white population.  Dramatic differences between the extent of the various
cerebrovascular risk factors are thought to exist among minority populations
as a whole.  Women appear to comprise an important population at risk for
stroke.  Previous assumptions regarding the hormonal protection against heart
disease and stroke are now being brought into question.  Recent changes in
employment patterns and lifestyles of women may be placing them in high-risk
categories in a manner previously unrecognized.  Whereas some factors, such as
transient ischemic attacks, are well known, the existence of other factors and
the interrelationship between various predisposing factors remain unclear.
Limited information is available regarding differences between stroke
subtypes, although clinical evidence suggests that such differences may exist.
 
RESEARCH GOALS AND SCOPE
 
The Division of Stroke and Trauma is seeking investigator-initiated research
grant applications for basic, applied, and clinical studies related, in the
 
            NIH GUIDE - Vol. 19, No. 36, October 5, 1990 - Page 7
broadest sense, to the etiology, prevention, early diagnosis, and treatment of
stroke, including rehabilitation, as these may relate to blacks, other
minorities, and women.
 
Examples of important research topics for consideration might include, but
should not necessarily be limited to:
 
  o  longitudinal epidemiology of the distribution and inter-relation
     between risk factors;
 
  o  relation of outcome from stroke to the differences in diagnostic
     methodology, acute management, post-stroke care, rehabilitation,
     and recurrent stroke;
 
  o  evaluation of treatment factors, including treatment compliance, in
     these special populations;
 
  o  special problems of blacks, other minorities, or women that may
     have an impact on the identification, diagnosis, treatment,
     management, follow-up, or long-term outcome;
 
  o  evaluation of emerging techniques for the analysis, diagnosis,
     treatment, and prevention of cerebrovascular disease; and
 
  o  comparative studies of identifiable populations at risk for stroke.
 
MECHANISM OF SUPPORT
 
The support mechanism for grants in this area will be the usual
investigator-initiated research project grant (R01), the program project grant
(P01), and the center grant (P50).  Under these mechanisms, the principal
investigator and any participating investigators will plan, direct, and
perform the research.  Applicants for program project grants should contact
the NINDS representative listed below as early as possible in the planning
stages.
 
APPLICATION AND REVIEW PROCEDURES
 
Applications must be prepared on form PHS 398 (rev.  10/88) according to the
instructions included in the application kit.  These kits are available from
the business offices of most institutions eligible to receive Federal grants
or from the Division of Research Grants, NIH.  Applications for program
project grants should request, from the address below, a copy of the NINDS
GUIDELINES FOR THE PREPARATION OF A PROGRAM PROJECT GRANT APPLICATION.
 
Receipt dates for new research project grant (R01) applications and for
program project grant (P01) and center grant (P50) applications are February
1, June 1, and October 1.
 
On page 1 of form PHS 398, check "yes" in item 2 and Type:  "STROKE IN BLACKS,
OTHER MINORITIES, AND WOMEN, PA-91-01."
 
Use the mailing label provided in the application kit to mail the signed
original and six exact copies to:
 
Application Receipt Office
Division of Research Grants
National Institutes of Health
Westwood Building, Room 240
Bethesda, MD  20892**
 
If the application is for a program project or center grant, please send the
original and four copies to the Division of Research Grants.  An additional
two copies sent to the address below would be useful for expediting the
processing of applications for these multidisciplinary efforts.  Any questions
concerning this should be directed to:
 
Dr. Patricia A. Grady
Division of Stroke and Trauma, NINDS
Federal Building, Room 8A13
Bethesda, MD  20892
Telephone:  (301) 496-4226
 
Research project grant (R01) applications will be reviewed for scientific and
technical merit by an appropriate study section in the Division of Research
Grants.  Program project grant (P01) and center grant (P50) applications will
be reviewed according to the assigned Institute's prevailing practice.
Secondary review will be by an appropriate National Advisory Council.
 
            NIH GUIDE - Vol. 19, No. 36, October 5, 1990 - Page 8
This program is described in the Catalog of Federal Domestic Assistance,
Number 93.853, Clinical Research Related to Neurological Disorders, and
93.854, Biological Basis Research in the Neurosciences.  Grants will be
awarded under the authority of the Public Health Service Act, Title IV,
Section 301 (Public Law 78-410, as amended:  42 USC 241) and administered
under PHS grant policies and Federal Regulations 42 CFR Part 52 and 45 CFR 74.
This program is not subject to Health Services Agency review of the
intergovernmental review requirements of Executive Order 12372.
 
This announcement is a revision of the Ongoing Program Announcement entitled,
"Cerebrovascular Disease in Blacks and Other Minorities," that appeared in the
NIH GUIDE For Grants and Contracts, Volume 16, Number 10, March 13, 1987,
pages 5-6.

**THE MAILING ADDRESS GIVEN FOR SENDING APPLICATIONS TO THE DIVISION OF
RESEARCH GRANTS OR CONTACTING PROGRAM STAFF IN THE WESTWOOD BUILDING IS THE
CENTRAL MAILING ADDRESS FOR THE NATIONAL INSTITUTES OF HEALTH.  APPLICANTS WHO
USE EXPRESS MAIL OR A COURIER SERVICE ARE ADVISED TO FOLLOW THE CARRIER'S
REQUIREMENTS FOR SHOWING A STREET ADDRESS.  THE ADDRESS FOR THE WESTWOOD
BUILDING IS:
 
5333 Westbard Avenue
Bethesda, Maryland 20816

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 
 
            NIH GUIDE - Vol. 19, No. 36, October 5, 1990 - Page 9