Subject: (Copy) NIH Guide Vol. 18, No. 35, October 6, 1989, Part 1 (final,RF
From: Dot Baker <[email-masked]>
To: [email-masked]
Date: Thu, 05 Oct 89 11:22 EST

Paul,
    This is the October 6, l989 NIH Guide.  Please post to list server
as NIHGUIDE.100689.
       Thanks,   Dottie
 ---------------------------- Text of forwarded message -----------------------
     
Subject: NIH Guide Vol. 18, No. 35, October 6, 1989, Part 1 (final,RFAs next)

     

     
     
Vol. 18, No. 35, October 6, 1989

                     DATED ANNOUNCEMENTS (RFPs AND RFAs)

STUDY OF STEROID CONTRACEPTIVES AND NEOPLASIA (Sources Sought) .(84/118)..... 1
National Institute of Child Health and Human Development
Index:  CHILD HEALTH, HUMAN DEVELOPMENT

THE ROLE OF THE PLACENTA IN TRANSMISSION AND TREATMENT OF HIV
INFECTION IN THE NEWBORN (RFA) ......................(121/177, 324/552)...... 1
National Institute of Child Health and Human Development
Index:  CHILD HEALTH, HUMAN DEVELOPMENT

                        ONGOING PROGRAM ANNOUNCEMENTS

NATIONAL RESEARCH SERVICE AWARDS FOR INSTITUTIONAL RESEARCH TRAINING
IN HUMAN IMMUNODEFICIENCY VIRUS (HIV) INFECTION ACQUIRED
IMMUNODEFICIENCY SYNDROME (AIDS) .........................(183/230).......... 2
Alcohol, Drug Abuse, and Mental Health Administration
Index:  ALCOHOL, DRUG ABUSE, MENTAL HEALTH

NATIONAL RESEARCH SERVICE AWARDS FOR INDIVIDUAL FELLOWS IN HUMAN
IMMUNODEFICIENCY VIRUS (HIV) INFECTION ACQUIRED IMMUNODEFICIENCY
SYNDROME (AIDS) ..........................................(241/286).......... 3
Alcohol, Drug Abuse, and Mental Health Administration
Index:  ALCOHOL, DRUG ABUSE, MENTAL HEALTH

     

     

     

     

     

     

     

     

     

     

     

     

     

     
                     DATED ANNOUNCEMENTS (RFPs AND RFAs)

STUDY OF STEROID CONTRACEPTIVES AND NEOPLASIA
     
SOURCES SOUGHT SYNOPSIS:  NICHD Contract N01-HD-52901
     
P.T. 34; K.W. 0750020, 0760085, 0715035, 0755018
     
National Institute of Child Health and Human Development
     
The National Institute of Child Health and Human Development is planning to
negotiate an increase in the requirements of contract N01-HD-52901 with the
Fred Hutchinson Cancer Research Center, Seattle, Washington, using other than
full and open competition.  The contract currently involves the initial
analysis and interpretation of data from the World Health Organization Study
of Neoplasia and Steroid Contraceptives (WHO Study), on the relationship
between the use of oral contraceptives and other steroid contraceptives
(primarily depo-medroxyprogesterone acetate), and the occurrence in women of
cancer of the breast and reproductive tract, i.e., the endometrium, ovary and
cervix.  The Government intends to expand the data analysis efforts to include
additional analyses of this data set for topics of interest.  The effort
involved is expected to require approximately 3 person-years.  The
determination to use other than full and open competition will be made in
accordance with 41 USC 253 (c) (1) as set forth in FAR 6.302-1.  The proposed
source, by virtue of their understanding and utilization of this data during
the course of the current contract, has developed the expertise and has sole
access to the WHO Study data.  The purpose of this synopsis is to determine
whether there are other sources with the requisite qualifications to perform
the work described above.  Organizations who believe they are qualified to
perform this shall provide capability statements within 45 days of publication
of this synopsis to the following address:
     
Contracts Management Section, NICHD
National Institutes of Health
Executive Plaza North, Room 610
6130 Executive Boulevard
Rockville, Maryland  20852

THE ROLE OF THE PLACENTA IN TRANSMISSION AND TREATMENT OF HIV INFECTION
IN THE NEWBORN
     
RFA AVAILABLE:  89-HD-10
     
P.T. 34; K.W. 1002034, 0413002, 0715008, 0715125, 0403020, 0710070
     
National Institute of Child Health and Human Development
     
Application Receipt Date:  January 17, 1990
     
The National Institute of Child Health and Human Development (NICHD) invites
grant applications to support basic research on the role of the placenta in
transmitting infection from mother to infant and its role in potential in
utero therapies for HIV infection.  The research areas may include but are not
limited to:  (1) leucocyte antigen immunohistochemistry, in situ hybridization
and electron microscopy of the placenta to identify virus infected cells or
other cells that may be infected by HIV and/or play a role in transport of the
virus from mother to infant; these tests should be correlated with newborn HIV
infection to determine the predictive value of viral antigen detection; (2)
studies of the role of maternal antibody(ies) in blocking the transmission of
HIV infection from mother to infant; (3) leucocyte antigen
immunohistochemistry, in situ hybridization and electron microscopy of the
products of conception to understand the timing of fetal exposure to HIV and
determine the risk of fetal infection; (4) studies of the pharmacokinetics of
antiretroviral and other chemotherapeutic agents across the placenta to the
fetus to determine the success of transport, efficacy and risk of
teratogenesis; (5) gross morphologic and histologic analyses of the effect of
HIV infection on placental development and function.
     
Inclusion of women and minorities are encouraged.  If they are excluded,
reasons for this exclusion must be included in the application.
     
MECHANISM OF SUPPORT
     
Support will be available through the traditional research grant (RO1).
Support for grants is contingent upon receipt of appropriated funds.  It is
anticipated that four to six meritorious applications will be funded.
     
                  Vol. 18, No. 35, October 6, 1989 - Page 1
APPLICATION PROCEDURE
     
Application must be submitted on form PHS 398 (revised 10/88).
     
ADDITIONAL INFORMATION
     
Potential applicants are encouraged to request further information by
telephoning:
     
Pamela Stratton, M.D.
Pediatric, Adolescent, and Maternal AIDS Branch
Center for Research for Mothers and Children
National Institute of Child Health and Human Development
EPN, Room 630-P
6130 Executive Boulevard
Rockville, Maryland  20892
Telephone:  (301) 496-7339

                        ONGOING PROGRAM ANNOUNCEMENTS

NATIONAL RESEARCH SERVICE AWARDS FOR INSTITUTIONAL RESEARCH TRAINING IN HUMAN
IMMUNODEFICIENCY VIRUS (HIV) INFECTION ACQUIRED IMMUNODEFICIENCY SYNDROME
(AIDS)
     
P.T. 44; K.W. 0715008, 0720005, 0404003, 0404009, 0715095
     
Alcohol, Drug Abuse, and Mental Health Administration
     
The National Institute on Drug Abuse (NIDA) is initiating a new program in
AIDS and HIV-related research and along with the National Institute of Mental
Health (NIMH) and the National Institute on Alcohol Abuse and Alcoholism
(NIAAA), seek applications for research training in the areas of mental
health, alcoholism and drug abuse as related to the HIV syndrome.  The
applicant institution must have the staff and facilities to conduct the
proposed research training and in a suitable environment for performing high
quality work.  Awards for institutional grants may be made for project periods
of up to five years.  In FY l990, a total of $600,000 (NIDA), $2,507,000
(NIMH), and $338,000 (NIAAA) will be available for institutional and
individual NRSAs related to HIV.  Availability and amount of funds for future
years are contingent upon annual appropriations.  NIDA, NIMH, and NIAAA will
accept applications in response to this announcement under the Public Health
Service receipt dates for NRSA applications:  May 10, September 10, January
10.  Potential applicants may also wish to see the NIDA/NIMH/NIAAA
announcement in this issue for individual fellowships.  Potential applicants
interested in obtaining further information should contact:
     
Charles Sharp, Ph.D.
Chairman, Fellowship/Training
National Institute on Drug Abuse
Room l0A-31
Telephone:  (301) 443-6300
     
Ellen S. Stover, Ph.D.
AIDS Coordinator
National Institute of Mental Health
Room 17C-04
Telephone:  (301) 443-7281
     
David Lozosky, M.D., Ph.D.
AIDS Coordinator
National Institute on Alcohol Abuse and Alcoholism
Room l4C-20
Telephone:  (301) 443-4223
     
The mailing address for all of the above is:
     
5600 Fishers Lane
Rockville, Maryland  20857

     

     

     
                  Vol. 18, No. 35, October 6, 1989 - Page 2
NATIONAL RESEARCH SERVICE AWARDS FOR INDIVIDUAL FELLOWS IN HUMAN
IMMUNODEFICIENCY VIRUS (HIV) INFECTION ACQUIRED IMMUNODEFICIENCY SYNDROME
(AIDS)
     
P.T. 22; K.W. 0715008, 0720005, 0404003, 0404009, 0715095
     
Alcohol, Drug Abuse, and Mental Health Administration
     
The National Institute on Drug Abuse (NIDA) is initiating a new program in
AIDS- and HIV-related research and along with the National Institute of Mental
Health (NIMH) and the National Institute on Alcohol Abuse and Alcoholism
(NIAAA), seek applications for research training in the areas of mental
health, alcoholism and drug abuse as related to the HIV syndrome.  Applicants
must propose research training in specified areas and demonstrate that the
proposed program offers them an opportunity to use and enhance their skills
and knowledge.  In FY l990, a total of $600,000 (NIDA), $2,507,000 (NIMH), and
$338,000 (NIAAA) will be available for institutional and individual NRSAs
related to HIV.  Availability and amount of funds for future years are
contingent upon annual appropriations.  NIDA, NIMH, and NIAAA will accept
applications in response to this announcement under the Public Health Service
receipt dates for NRSA applications:  May 10, September 10, January 10.
Potential applicants interested in obtaining further information should
contact:
     
Charles Sharp, Ph.D.
Chairman, Fellowship/Training
National Institute on Drug Abuse
Room l0A-31
Telephone:  (301) 443-6300
     
Ellen S. Stover, Ph.D.
AIDS Coordinator
National Institute of Mental Health
Room 17C-04
Telephone:  (301) 443-7281
     
David Lozosky, M.D., Ph.D.
AIDS Coordinator
National Institute on Alcohol Abuse and Alcoholism
Room l4C-20
Telephone:  (301) 443-4223
     
The mailing address for all of the above is:
     
5600 Fishers Lane
Rockville, Maryland  20857

     

     

     

     

     

     

     

     

     

     

     
                  Vol. 18, No. 35, October 6, 1989 - Page 3