Subject: (Copy) NIH Guide Vol. 18, No. 39, November 3, 1989, Part 1 (final,
From: Dot Baker <[email-masked]>
To: [email-masked]
Date: Fri, 03 Nov 89 09:11 EST

Good Morning Paul,
    This is the latest NIH Guide.  Please post it as NIHGUIDE.110389.
        ALSO, I have had several calls complaining about the list
server.  It seems as if all of them are receiving four or five copies
of each message being sent over the wire.  Is there any way you can
correct this?  Please advise.
     Thanks.  Have a nice weekend.
                                  Dottie
 ---------------------------- Text of forwarded message -----------------------
     
Subject: NIH Guide Vol. 18, No. 39, November 3, 1989, Part 1 (final, no RFAs pre
X-comment: NIH Guide (including TOC) contained 7 pages (560 lines)

     

     
     
Vol. 18, No. 39, November 3, 1989

                     DATED ANNOUNCEMENTS (RFPs AND RFAs)

TRIAL OF CALCIUM SUPPLEMENTATION IN PREGNANCY FOR THE PREVENTION OF
PREECLAMPSIA AND PRETERM BIRTH (RFP) .......................(84/120)......... 1
National Institute of Child Health and Human Development
Index:  CHILD HEALTH, HUMAN DEVELOPMENT

THE DATA COORDINATING CENTER FOR THE NICHD TRIAL OF CALCIUM
SUPPLEMENTATION IN PREGNANCY FOR THE PREVENTION OF PREECLAMPSIA
AND PRETERM BIRTH (RFP) ....................................(123/164)........ 1
National Institute of Child Health and Human Development
Index:  CHILD HEALTH, HUMAN DEVELOPMENT

IN VIVO TEST SYSTEMS FOR COMBINED CHEMOTHERAPIES AGAINST HIV (RFP) .......... 2
National Institute of Allergy and Infectious Diseases       (167/207)
Index:  ALLERGY, INFECTIOUS DISEASES

IN VITRO TEST SYSTEMS FOR COMBINED CHEMOTHERAPIES AGAINST HIV (RFP) ......... 2
National Institute of Allergy and Infectious Diseases       (210/255)
Index:  ALLERGY, INFECTIOUS DISEASES

NOTICE - CLAUDE D. PEPPER GERIATRIC RESEARCH AND TRAINING CENTERS (RFA) ..... 3
National Institute on Aging                                 (258/284)
Index:  AGING

                        ONGOING PROGRAM ANNOUNCEMENTS

INVESTIGATIONS INTO METHODS THAT REPLACE OR REDUCE VERTEBRATE ANIMALS
USED IN RESEARCH, OR LESSEN THEIR PAIN AND DISTRESS ........(290/533)........ 3
National Institutes of Health
Alcohol, Drug Abuse, and Mental Health Administration
Index:  NATIONAL INSTITUTES OF HEALTH
        ALCOHOL, DRUG ABUSE, AND MENTAL HEALTH ADMINISTRATION

     

     

     

     

     

     

     

     

     

     
     
                     DATED ANNOUNCEMENTS (RFPs AND RFAs)

TRIAL OF CALCIUM SUPPLEMENTATION IN PREGNANCY FOR THE PREVENTION OF
PREECLAMPSIA AND PRETERM BIRTH
     
RFP AVAILABLE:  NICHD-PRP-90-06
     
P.T. 34; K.W. 0715160, 0745027, 0710095, 0715115, 0755015
     
National Institute of Child Health and Human Development
     
The National Institute of Child Health and Human Development has a requirement
for a clinical trial to determine if calcium supplementation during pregnancy
has a preventive effect on the incidence of pregnancy-induced hypertension
(PIH) and preterm birth.  This project will consist of a double-blind
randomized trial and is to be carried out by 2-4 clinical centers and a data
coordinating center.  An attempt will be made to recruit at least 5,400
eligible women so that there will be a final study sample of at least 3,600.
Offerors will be expected to include plans for the recruitment of eligible
minority women for this study.  The data necessary for this project will be
collected through questionnaires, interviews, and clinical and laboratory
examinations.
     
This announcement for the clinical centers to perform the trials is a new
solicitation.  Solicitation for proposals for the data coordinating center for
this project will be announced under a different Request for Proposals (RFP).
This issuance of the clinical trial RFP will be on or about November 6, 1989,
and the proposals are due by 4:00 pm (Local Time), January 10, 1990.  Those
organizations desiring a copy of the above RFP may send their written request
with two self-addressed mailing labels to:
     
Mrs. Lynn Salo, Contract Specialist
NICHD, OGC, CMS
Executive Plaza North, Room 515
9000 Rockville Pike
Bethesda, Maryland  20892
     
All responsible sources may submit a proposal for consideration.  This
advertisement does not commit the Government to award a contract.

THE DATA COORDINATING CENTER FOR THE NICHD TRIAL OF CALCIUM SUPPLEMENTATION IN
PREGNANCY FOR THE PREVENTION OF PREECLAMPSIA AND PRETERM BIRTH
     
RFP AVAILABLE:  NICHD-PRP-90-07
     
P.T. 34; K.W. 0715160, 0745027, 0710095, 0715115, 0755015, 0755018
     
National Institute of Child Health and Human Development
     
The National Institute of Child Health and Human Development is seeking
organizations that are small businesses to coordinate a clinical trial of
Calcium Supplementation in Pregnancy for the Prevention of Preeclampsia and
Preterm Birth.  This project consists of a double-blind, randomized trial and
is to be carried out by 2-4 clinical centers and a data coordinating center.
An attempt will be made to recruit at least 5,400 eligible women so that there
will be a final study sample of at least 3,600.  The Data Coordinating Center
must be capable of providing daily assistance to the clinical investigators at
the data collection sites, insuring that the protocol is followed, assuring
the quality of data collected, and providing feedback to the steering
committee or the Project Officer on study progress within a short turn around
time.
     
This announcement for the Data Coordinating Center is a new solicitation.  The
clinical trials project will be announced under a different Request for
Proposals (RFP).  The issuance of the Data Coordinating Center RFP will be on
or about November 6, 1989, and the proposals are due by 4:00 pm (Local Time),
January 10, 1990.  Those organizations desiring a copy of the above referenced
RFP may send their written request with two self-addressed mailing labels to:
     
Mrs. Lynn Salo, Contract Specialist
NICHD, OGC, CMS
Executive Plaza North, Room 515
9000 Rockville Pike
Bethesda, Maryland  20892

     
                  Vol. 18, No. 39, November 3, 1989 - Page 1
(THIS IS A 100% SET-ASIDE FOR SMALL BUSINESS, SIC 7379-- Computer related
services not otherwise classified.) All responsible small business sources may
submit a proposal which will be considered.  This advertisement does not
commit the Government to award a contract.

IN VIVO TEST SYSTEMS FOR COMBINED CHEMOTHERAPIES AGAINST HIV
     
RFP AVAILABLE:  NIH-NIAID-DAIDS-90-24
     
P.T. 34; K.W. 0745005, 0755010, 0715008, 0755060
     
National Institute of Allergy and Infectious Diseases
     
The Developmental Therapeutics Branch of the National Institute of Allergy and
Infectious Diseases (NIAID), NIH, has a requirement for contract assistance to
provide in vivo test systems for screening combinations of therapies against
HIV.  Evaluation systems may use HIV or other animal retrovirus systems.
These model systems will be used by the Division of AIDS of the NIAID in its
efforts to assist in the development of anti-infective drugs and therapies, to
better understand interactions between therapeutic agents (synergy, adverse
effect, etc.), and to optimize administration of combined therapies (route,
schedule, etc.). The model systems to be investigated should reflect the
clinical, immunological and virological aspects of HIV infection in humans.
It is anticipated that this information will permit the improved treatment of
HIV infections in humans.
     
This is an announcement for an anticipated Request for Proposals (RFP).
RFP-NIH-NIAID-DAIDS-90-24 shall be issued on or about November 3, 1989, with a
closing date tentatively set for January 11, 1990.  The Institute expects to
make approximately two awards from this solicitation.
     
Requests for the RFP should be directed in writing to:
     
Mary Anne Glitz
Contract Management Branch
Control Data Building, 6003 Executive Blvd., Room 214P
National Institute of Allergy and Infectious Diseases
National Institutes of Health
Bethesda, Maryland  20892
Telephone:  (301) 496-1642
     
To receive a copy of the RFP, please supply this office with 2 self-addressed
mailing labels.  All inquiries must be in writing.  All responsible sources
may submit a proposal which will be considered.
     
This advertisement does not commit the Government to award a contract.

IN VITRO TEST SYSTEMS FOR COMBINED CHEMOTHERAPIES AGAINST HIV
     
RFP AVAILABLE:  NIH-NIAID-DAIDS-90-23
     
P.T. 34; K.W. 0745005, 0755010, 0715008, 0755060
     
National Institute of Allergy and Infectious Diseases
     
The Developmental Therapeutics Branch of the National Institute of Allergy and
Infectious Diseases (NIAID), NIH, has a requirement for contract assistance to
provide in vitro test systems for screening combinations of therapies against
HIV.  Evaluation systems must be a standardized cell-based assay using HIV
infection of t-cell lines, macrophages and fresh peripheral blood lymphocytes;
evaluations must include efficacy and cytotoxicity measures.  Additional
evaluations include cell uptake, mechanisms of antagonism or synergy, cellular
metabolism, immunological effects, and efficacy against drug-resistant strains
of virus.  These model systems will be used by the Division of AIDS of the
NIAID in its efforts to assist in the development of anti-infective drugs and
therapies, to better understand interactions between therapeutic agents
(synergy, adverse effect, etc.), and to understand mechanisms of action of
therapeutic agents.  The model systems should be relevant to therapies
directed against HIV infection in humans and provide information that will
permit the improved treatment of patients infected with HIV.
     
This is an announcement for an anticipated Request for Proposal (RFP).
RFP-NIH-NIAID-DAIDS-90-23 will be issued on or about November 3, 1989, with a
closing date tentatively set for January 10, 1990.  The Institute expects to
make approximately three awards from this solicitation.

                  Vol. 18, No. 39, November 3, 1989 - Page 2
Requests for the RFP shall be directed in writing to:
     
Mary Anne Glitz
Contract Management Branch
Control Data Building, 6003 Executive Blvd., Room 214P
National Institute of Allergy and Infectious Diseases
National Institutes of Health
Bethesda, Maryland  20892
Telephone:  (301) 496-1642
     
To receive a copy of the RFP, please supply this office with 2 self-addressed
mailing labels.  All inquiries must be in writing.  All responsible sources
may submit a proposal which will be considered.
     
This advertisement does not commit the Government to award a contract.

NOTICE - CLAUDE D. PEPPER GERIATRIC RESEARCH AND TRAINING CENTERS
     
P.T. 04, 44; K.W. 0710010, 0720005, 0710030
     
RFA:  AG-89-06
     
Application Receipt Date:  February 15, 1990
     
National Institute on Aging
     
The National Institute on Aging's Geriatric Research and Training Centers
grant program (P30), announced in the NIH Guide for Grants and Contracts, Vol.
18, No. 27, August 11, 1989, is retitled the Claude D. Pepper Geriatric
Research and Training Centers grant program as a tribute to the memory of
Senator Pepper.
     
A copy of the complete Request for Applications and the Geriatric Research and
Training Centers Guidelines may be obtained from:
     
Stanley L. Slater, M.D.
Director, Geriatric Research and Training Program
Geriatrics Branch
National Institute on Aging
Building 31, Room 5C27
9000 Rockville Pike
Bethesda, Maryland  20892
Telephone:  (301) 496-6761

                        ONGOING PROGRAM ANNOUNCEMENTS

INVESTIGATIONS INTO METHODS THAT REPLACE OR REDUCE VERTEBRATE ANIMALS USED IN
RESEARCH, OR LESSEN THEIR PAIN AND DISTRESS
     
P.T. 34; K.W. 0755020, 0780010, 0780015, 0780020
     
National Institutes of Health
Alcohol, Drug Abuse, and Mental Health Administration
     
Application Receipt Dates:  February 1, June 1, October 1
     
BACKGROUND
     
The National Institutes of Health (NIH) and the Alcohol, Drug Abuse, and
Mental Health Administration invites grant applications for investigations
into research methods that do not use animals, use fewer animals, or that
produce less pain and distress in animals used for research.
     
Biomedical research will be most effectively advanced by the continuous
application of a combination of models in a complementary and interactive
manner, rather than by concentrating on any one or a few kinds of model
systems.  Each system, whether mammalian or nonmammalian, has its own unique
advantages and limitations.  Because of a continued, wide interest in the
development of nonmammalian models for biomedical research, this Program
Announcement, issued in April 1988, is being reissued to encourage
applications in this area.
     
Proposals for the study of invertebrates, lower vertebrates, microorganisms,
cell and tissue culture systems, or mathematical approaches should be regarded
as having the same potential relevance to biomedical research as proposals for
     
                  Vol. 18, No. 39, November 3, 1989 - Page 3
work on systems that are phylogenetically more closely related to humans.
Experience indicates that information yielded by such systems can increase
substantially the knowledge of human function.
     
Animals are essential to the advancement of knowledge in the biomedical
sciences.  Nonmammalian research methods can, and do, provide additional
opportunities to advance our understanding of biological processes.  For
example, biological models or model systems derived from, or consisting of,
nonmammalian organisms, or cell and tissue culture systems, may provide
valuable insights into mechanisms of biological functions that are more
difficult to obtain from studies of whole vertebrate animals.  Such
technologies often permit studies that otherwise would be impossible to
perform.  Mathematical modeling is another useful investigational strategy
when closely coupled to biological experimentation, and there are
opportunities for mathematical modeling in many areas of biomedical research.
Non-invasive experimental techniques, such as those commonly used for human
subjects, which permit studies of biological processes in intact animals, can
reduce the number of experimental animals since multi-step phenomena can be
observed in a single subject.
     
Many strategies are currently in place to reduce the pain and distress of
laboratory animals; however, new methods and technologies are encouraged.
     
RESEARCH GOALS
     
Grant applications are requested for projects that will increase the extent
and depth of knowledge needed to develop methods of biomedical research that:
     
  o  do not require the use of vertebrate animals o reduce the number of
     vertebrate animals used in research o produce less pain and
     distress in vertebrate animals than methods currently used o
     validate or demonstrate the reliability of non-animal methods o
     expand non-vertebrate animal research methods that have been found
     valid and reliable
     
MECHANISM OF SUPPORT
     
The support mechanism for this program will be the traditional
investigator-initiated research project grant.  Under this mechanism, the
applicant will plan, direct, and carry out the research program.  The project
period during which the research will be conducted should adequately reflect
the time required to accomplish the stated goals and be consistent with the
policy for grant support.  Support will be provided for up to five years
(renewable for subsequent periods) subject to the availability of funds and
progress achieved.
     
Research grant applications may be submitted by both nonprofit and
profit-making organizations and institutions, State or local governments and
their agencies, and eligible agencies of the Federal Government.
     
APPLICATIONS AND REVIEW PROCEDURES
     
Applications in response to this solicitation will be appropriately peer
reviewed for scientific and technical merit.  They will be judged on the
overall scientific merit of the proposed research, potential significance of
the research findings, adequacy of methodology, availability of necessary
facilities, and the qualifications of the research team.  A secondary review
for policy and program relevance to the research needs and missions of the
Bureau, Institute, or Division to which the proposal is assigned will be made
by the respective National Advisory Councils.
     
Applications should be completed using PHS Form 398, "Application for Public
Health Service Grant".  Send the original and six copies of the application to
the Division of Research Grants, NIH, as described in PHS Form 398.
     
It is important that applicants enter "NONMAMMALIAN RESEARCH METHODS" on line
2 for the response to specific program announcement.
     
Applicants are encouraged to contact Dr. Ramm at the address below prior to
submitting an application:
     
Dr. Louise E. Ramm
Biological Models and Materials Resources Program, DRR/NIH
Westwood Building, Room 853
5333 Westbard Avenue
Bethesda, Maryland  20892

     
                  Vol. 18, No. 39, November 3, 1989 - Page 4
FOR FURTHER INFORMATION CONTACT:
     
Division of Research Resources
Dr. Louise E. Ramm
Biological Models and Materials Resources Program
Westwood Building, Room 853
Bethesda, Maryland  20892
Telephone:  (301) 496-5175
     
National Cancer Institute
Dr. J.A.R. Mead
Chief, Grants and Contracts Operations Branch
Developmental Therapeutics Program
Division of Cancer Treatment
Executive Plaza North, Room 832
Bethesda, Maryland  20892
Telephone:  (301) 496-8783
     
National Center for Nursing Research
Dr. Jan Heinrich
Director, Extramural Programs
Building 38A, Room 2BE17
Bethesda, Maryland  20892
Telephone:  (301) 496-0523
     
National Eye Institute
Dr. Michael Oberdorfer
Program Director, Amblyopia and Visual Processing
Building 31, Room 6A47
Bethesda, Maryland  20892
Telephone:  (301) 496-5301
     
National Institute of Allergy and Infectious Diseases
Dr. Luz A. Froehlich
Deputy Director, Extramural Activities Program
Westwood Building, Room 703
Bethesda, Maryland  20892
Telephone:  (301) 496-7688
     
National Institute on Aging
Dr. DeWitt Hazzard
Head, Resource Development
Biomedical Research and Clinical Medicine
Building 31, Room 5C21
Bethesda, Maryland  20892
Telephone:  (301) 496-6402
     
National Institute of Arthritis and Musculoskeletal and Skin Diseases
Dr. Steven J. Hausman
Deputy Director, Extramural Program
Westwood Building, Room 403
Bethesda, Maryland  20892
Telephone:  (301) 496-7495
     
National Institute of Child Health and Human Development
Ms. Hildegard Topper
Special Assistant
Office of the Director
Building 31, Room 2A04
Bethesda, Maryland  20892
Telephone:  (301) 496-0104
     
National Institute of Diabetes and Digestive and Kidney Diseases
Dr. Walter Stolz
Director, Division of Extramural Activities
Westwood Building, Room 657
Bethesda, Maryland  20892
Telephone:  (301) 496-7277
     
National Institute of Dental Research
Dr. G. Wayne Wray
Deputy Director, Extramural Program
Westwood Building, Room 502
Bethesda, Maryland  20892
Telephone:  (301) 496-7748

     
     
                  Vol. 18, No. 39, November 3, 1989 - Page 5
National Institute of Environmental Health Sciences
Dr. Jerry Robinson
Scientific Programs Branch
Division of Extramural Research and Training
P.O. Box 12233
Research Triangle Park, North Carolina  27729
Telephone:  (919) 541-7724 or
            (FTS NUMBER) 8-629-7724
     
National Institute of General Medical Sciences
Dr. David Wolff
Deputy Associate Director for Program Activities
Westwood Building, Room 955
Bethesda, Maryland  20892
Telephone:  (301) 496-7063
     
National Heart, Lung, and Blood Institute
Dr. Henry G. Roscoe
Deputy Director, Division of Extramural Affairs
Westwood Building, Room 7A17
Bethesda, Maryland  20892
Telephone:  (301) 496-7225
     
National Institute of Neurological Disorders and Stroke
Dr. Eugene Streicher
Director, Division of Fundamental Neurosciences
Federal Building, Room 916
Bethesda, Maryland  20892
Telephone:  (301) 496-5745
     
National Institute on Alcohol Abuse and Alcoholism
Dr. Helen Chao
Acting Deputy Director, Division of Basic Research
Parklawn Building, Room 14C-10
5600 Fishers Lane
Rockville, Maryland  20857
Telephone:  (301) 443-2530
     
National Institute on Drug Abuse
Dr. Roger Brown
Chief, Neuroscience Research Branch
Division of Preclincial Research
Parklawn Building, Room 10A-31
5600 Fishers Lane
Rockville, Maryland  20857
Telephone:  (301) 443-6975
     
National Institute of Mental Health
Dr. Ronald Schoenfeld
Acting Chief, Neurosciences Research Branch
5600 Fishers Lane, Room 11-105
Rockville, Maryland  20857
Telephone:  (301) 443-3948

     

     

     

     

     

     

     

     

                  Vol. 18, No. 39, November 3, 1989 - Page 6