Subject: NIH GUIDE - RFA DK-91-14 - V20(24) 06/21/91
From: Dot Baker <[email-masked]>
To: [email-masked]
Date: Thu, 20 Jun 91 08:34 EST

Paul:
The NIH Guide has arrived.  It will be followed in 2 parts.
Please post this one to the NIH Listserver as:
NIHGUIDE RFA DK-91-14.910621.
If you have any questions or I haven't done something correctly,
please give me a call.  Thanks for your help.
                       Mary Broaddus
 
$$XID RFA DK9114 DK-91-14 P1O1 *****************************************
 
DIGESTIVE DISEASES CORE CENTERS
 
RFA:  DK-91-14
 
P.T. 04; K.W. 0715085, 0710030, 0785035
 
National Institute of Diabetes and Digestive and Kidney Diseases
 
Letter of Intent Receipt Date:  August 15, 1991
Application Receipt Date:  October 16, 1991
 
PURPOSE
 
The National Institute of Diabetes and Digestive Kidney Diseases (NIDDK)
invites applications for Digestive Diseases Core Center grants.  NIDDK
anticipates the award of one competitive Digestive Diseases Core Center
Grant in Fiscal Year 1992.
 
BACKGROUND
 
The NIDDK-supported Digestive Diseases Core Centers are part of an
integrated program of digestive disease related research support
provided by NIDDK.  These Centers have provided a focus for increasing
collaboration and improving the cost effectiveness of supported research
among groups of successful investigators at institutions with an
established comprehensive digestive diseases research base.  At least 50
percent of this research base must be supported by NIDDK.
 
OBJECTIVE AND SCOPE
 
The objective of the Core Centers is to bring together investigators
from relevant disciplines to enhance and extend the effectiveness of
research related to digestive diseases and their complications.  A Core
Center must be an identifiable unit within a single university medical
center or a consortium of cooperating institutions, including an
affiliated university.  The overall goal of the Core Center is to bring
together clinical and basic science investigators in a manner that will
enrich the effectiveness of digestive diseases research.  An existing
program of excellence in biomedical research in the area of digestive
diseases disorders is required.  This research must be in the form of
NIH-funded research projects, program projects, or other peer-reviewed
research that is in existence at the time of submission of a Center
grant application.  Close cooperation, communication, and collaboration
among all involved personnel of all professional disciplines are
ultimate objectives.
 
The Core Centers must have a central focus of research investigation.
The central focus must be a digestive disease or group of diseases; at
least half of the research must focus on this area.  Examples of a
central focus of research investigation include (but are not restricted
to) inflammatory bowel disease, peptic ulcer disease, pancreatic
disease, liver disease, and pediatric gastrointestinal disease.
Applicants should consult with NIDDK staff concerning plans for the
development of the Center and the organization of the application.
 
Digestive Diseases Core Centers are based on the core concept.  Cores
are defined as shared resources that enhance productivity or in other
ways benefit a group of investigators working in digestive diseases
centers to accomplish the stated goals of the Center.  Two other types
of activities may also be supported with Center funding:  a pilot and
feasibility program and an enrichment program.  The pilot and
feasibility program provides modest support for new initiatives or
feasibility research studies.  This program is directed at new
investigators and at investigators established in other research
disciplines with expertise that may be applied to digestive disease
research.  The Core Center grant may include limited funds for program
enrichment such as seminars, visiting scientists, consultants, and
workshops.
 
ELIGIBILITY
 
Nonprofit institutions within the United States may apply for Digestive
Diseases Core Center grants.
 
Applicant institutions must have an adequate base of established
programs of high quality in laboratory and/or clinical digestive
diseases-related research.  The quality of the programs must be evident
from the fact that they have been awarded support through peer-reviewed
competition, such as in the form of NIDDK research grants, cooperative
agreements, and contracts.
 
MECHANISM OF SUPPORT
 
The NIDDK expects to award one Digestive Diseases Core Center Grant in
the Fiscal Year 1992 on a competitive basis.  The receipt of one
competitive continuation application is anticipated.  This application
will compete for the award along with other applications received in
response to this Requests for Applications (RFA).  The anticipated award
will be for five years and is contingent upon the availability of
appropriated funds.  The requested budget may not exceed $700,000 direct
costs per year.  Any application exceeding this amount will be returned
to the applicant.  The current Center is supported at approximately
$700,000 total cost per year.  The general description and guidelines
for the digestive disease centers and consultation may be obtained from:
 
Technical Information
 
Tommie S. Tralka
Director, Digestive Diseases Centers Program
National Institute of Diabetes and Digestive and Kidney Diseases
Westwood Building, Room 3A15
Bethesda, MD  20892
Telephone:  (301) 496-9717
 
Business Information
 
Nancy Dixon
Supervisory Grants Management Specialist
National Institute of Diabetes and Digestive and Kidney Diseases
Westwood Building, Room 639
Bethesda, MD  20892
Telephone:  (301) 496-7467
 
REVIEW PROCEDURES
 
Applications for the Core Center grant will be evaluated by the NIH
grant peer review process.  Applications will be reviewed initially by
an ad hoc review group convened by the NIDDK and subsequently by the
National Diabetes and Digestive and Kidney Diseases Advisory Council.
Applications are unlikely to be reviewed by a site visit team;
therefore, the written application must be complete to facilitate review
without a site visit.  Extensive additional materials submitted
subsequent to the stated receipt date will not be accepted.
 
METHOD OF APPLYING
 
Letter of Intent:
 
Potential applicants are requested to submit a letter of intent by
August 15, 1991.  The letter of intent is non-binding, is not a
necessary requirement for submission of an application, and is not a
precondition for an award.  Letters of intent are requested for review
planning purposes.  The NIDDK will not respond to such letters.  The
letter of intent should include the name(s) of the Principal
Investigator and principal collaborators, descriptive titles of the core
facilities and pilot/feasibility projects, and the institution(s)
involved.  Letters of intent are to be sent to:
 
Dr. Robert Hammond
Chief, Review Branch
National Institute of Diabetes and Digestive and Kidney Diseases
Westwood Building, Room 406
Bethesda, MD  20892
 
Applicants from institutions that have a General Clinical Research
Center (GCRC) funded by the NIH National Center for Research Resources
may wish to identify the GCRC as a resource for conducting the proposed
research.  In such a case, a letter of agreement from either the GCRC
program director or Principal Investigator must be included with the
application.
 
Applications must be submitted using PHS 398 (rev.  10/88).  Check the
"YES" box in line 2 of the application face page and insert "DIGESTIVE
DISEASES CORE CENTERS, RFA DK-91-14."  THE RFA LABEL CONTAINED IN THE
APPLICATION KIT MUST BE AFFIXED TO THE BOTTOM OF THE FACE PAGE OF THE
ORIGINAL COPY OF THE APPLICATION.  FAILURE TO USE THIS LABEL COULD
RESULT IN DELAYED PROCESSING AND REVIEW OF THE APPLICATION.
 
Submit a signed, typewritten original of the application, including the
checklist and four signed, exact photocopies, in one package to:
 
Division of Research Grants
National Institutes of Health
Westwood Building, Room 240
Bethesda, MD  20892**
 
RECEIPT AND REVIEW SCHEDULE
 
Letter of Intent Receipt Date:      August 15, 1991
 
Application Receipt Date:           October 16, 1991
 
Initial Review Date:                Feb./Mar. 1992
 
National Digestive Diseases
Advisory Council Review Date:       May/June 1992
 
Anticipated Award Date:            September 1992
 
IMPORTANT:  At the time of submission, two additional copies of the
application must be sent under separate cover to:
 
Dr. Robert Hammond
Chief, Review Branch
National Institute of Diabetes and Digestive and Kidney Diseases
Westwood Building, Room 406
Bethesda, MD  20892
 
Applications must be received by October 16, 1991.  If an application is
received after that date, it will be returned.
 
This program is described in the Catalog of Federal Domestic Assistance
No. 93,848, Digestive Diseases and Nutrition.  Awards will be made under
the authority of the Public Health Service Act, Title III, Section 301
and Section 431 (b) (Public Law 78-410, as amended:  42 USC 241 and 42
USC 285c-5) and administered under PHS grant policies and Federal
Regulations 42 CFR Part 52 and CFR Part 74.  This program is not subject
to the intergovernmental review requirements of Executive Order 12372 or
Health Systems Agency review.