The 16th century heralded a new era for painting in the Netherlands and Germany. Northern artists were influenced by the great innovations in the South; many artists travelled to Italy to study; and the Renaissance concern for bringing modern science and philosophy into art was also evident in the North. There was, however, a difference of outlook between the two cultures. In Italy change was inspired by Humanism, with its emphasis on the revival of the values of classical antiquity. In the North, change was driven by another set of preoccupations: religious reform, the return to ancient Christian values, and the revolt against the authority of the Church.
The Renaissance in the North crystallized around the intense vision and realism of Dürer's work. Other painters in both Germany and the Netherlands followed the Northern impulse for precise observation and naturalism in the fields of landscape painting (Patinir and Bruegel) and portraiture (Holbein). As in Italy, the Northern Renaissance ended with a Mannerist phase. Mannerism was to last about a generation longer in the North than it did in Italy, where it was outmoded by 1600.