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[SANET-MG] red wine is medicine
Moderate red wine is great for the heart and prevents cancer in people as well
as diabetic rats.Too much red wine , however, makes the nose shine.
As discussed many times previously the polyphenol content of organic food makes
that food superior in preventing cancer and heart disease.
J. Agric. Food Chem., ASAP Article 10.1021/jf049295g S0021-8561(04)09295-7
Web Release Date: August 4, 2004
Red Wine Polyphenols Alone or in Association with Ethanol Prevent Hypertension,
Cardiac Hypertrophy, and Production of Reactive Oxygen Species in the
Insulin-Resistant Fructose-Fed Rat
Najim A. Al-Awwadi, Aurélie Bornet, Jacqueline Azay, Caroline Araiz, Sandrine
Delbosc, Jean-Paul Cristol, Nathalie Linck, Gérard Cros, and Pierre-Louis
Laboratoire de Pharmacologie et Physiopathologie Expérimentales, INSERM U376 and
Centre d'Oenologie, UMR 1083 Sciences pour l'Oenologie, Faculté de Pharmacie,
15 Avenue Charles Flahault, B.P. 14491, 34093 Montpellier Cedex 5, France, and
Laboratoire de Nutrition Humaine et Athérogénèse, Institut Universitaire de
Recherche Clinique, 34093 Montpellier Cedex 5, France
Received for review May 4, 2004. Revised manuscript received June 28, 2004.
Accepted June 28, 2004. We thank the French Ministry of Agriculture (Scientific
Council of the ONIVINS) for its financial support.
The effects of a red wine polyphenolic extract (RWPE), ethanol, or both combined
were evaluated in insulin resistant rats. Rats were fed for 6 weeks with
fructose (60%)-enriched food and force-fed with (a) water only (F group), (b)
aqueous solution of RWPE (100 mg/kg, FP group), (c) 10% (v/v) mixture of
ethanol and water (FE group), or (d) solution containing the same amount of the
RWPE and ethanol (FPE group). Animals fed a standard chow (C group) were used
for comparison purpose. After 6 weeks, blood pressure was higher in F (130.0
×b1 1.7 mm Hg) than in C animals (109.6 ×b1 0.9 mm Hg) and similar to the C
group in all other fructose-fed treatment groups. Relative heart weight was
higher in F (3.10 ×b1 0.05) than in C (2.78 ×b1 0.07) and significantly lower
in FP (2.92 ×b1 0.04) and FPE (2.87 ×b1 0.08 mg/g) than in F animals. Left
ventricle and aorta productions of reactive oxygen species (O2-) were higher in
F than in C groups and lowered by the RWPE but not by the ethanol treatment.
Ethanol but not the RWPE treatment reduced the degree of insulin resistance in
the fructose-fed rats. In summary, our study showed that polyphenols are able
to prevent cardiac hypertrophy and production of reactive oxygen species in the
insulin resistant fructose-fed rat.
Keywords: Polyphenols; ethanol; hypertension; cardiac hypertrophy; oxidative
stress; insulin resistance
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