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Dissertation Information for Minnie M. Johnson

NAME:
- Minnie M. Johnson

DEGREE:
- Ph.D.

DISCIPLINE:
- Library and Information Science

SCHOOL:
- Rutgers University (USA) (1983)

ADVISORS:
- Susan Artandi

COMMITTEE MEMBERS:
- Henry Voos
- Joseph I. Naus
- J. K. Weston

MPACT Status: Fully Complete

Title: THE USE OF BIBLIOMETRIC ANALYSIS TO PREDICT GENERATIONAL ACTIVITY OF CONGENERS AND PRODRUGS

Abstract: The objective of the study was to determine if a pattern existed in the literature documentation of a drug. If so, was the established pattern of a parent drug comparable to other drugs within its class? Does content analysis of the literature of a drug provide enough historical information to predict the activity of associated congeners or prodrugs? A bibliometric construct of patterns was formed by plotting literature relationships of six classes of drugs on time series graphs. Content analysis was utilized to explain the behavior of the literature over time.

The results of the study indicate that there is a relationship in the pattern of prototype drugs and their prodrugs/congeners when the prototype drug is not challenged within five years by a new drug. A relationship also exists when the certified indications remain constant between the prototype and new drugs.

The results of the content analysis of the literature of the drugs explains why the predictive patterns exist and why there is replication from class to class. The primary predictive powers of these analyses are based on the therapeutic applications of the prototype drug and thereafter, the innovative practices extended to it.

MPACT Scores for Minnie M. Johnson

A = 0
C = 0
A+C = 0
T = 0
G = 0
W = 0
TD = 0
TA = 0
calculated 2008-01-31 06:09:37

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Students under Minnie M. Johnson

ADVISEES:
- None

COMMITTEESHIPS:
- None