Dissertation Information for Joe Michael CherryNAME:
DEGREE:
DISCIPLINE:
SCHOOL: ADVISORS: COMMITTEE MEMBERS: MPACT Status: Incomplete - Not_Inspected Title: INTERNALLY LOCATED TELOMERIC SEQUENCES IN THE MICRONUCLEUS OF TETRAHYMENA THERMOPHILA
Abstract: "The internally located C(,4)A(,2) repeat blocks of the Tetrahymena thermophila micronuclear genome were found to be associated with a DNA element family. These micC(,4)A(,2) were shown to be closely associated with a highly conserved 30 bp sequence. This conserved sequence contains the recognition site for the restriction enzyme BstXl, which cuts the micronuclear genome infrequently. BstXl digestion of micronuclear DNA placed all the micC(,4)A(,2) repeat blocks close to a restriction cut end, and released two major forms of DNA element family designated Tel-1 (Tetrahymena element or Telomere containing element), which are 9.7 and 13.2 kb in length. This family of elements is proposed to be transposable. The C(,4)A(,2) repeats found as part of the terminal inverted repeats of the Tel-1 elements are proposed to be added during or subsequent to the act of transposition. It is proposed that a linear form of the Tel-1 element is acted upon the the telomere addition activity within the micronucleus. |
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Students under Joe Michael Cherry
ADVISEES:
- None
COMMITTEESHIPS:
- W. John MacMullen - University of North Carolina, Chapel Hill (2007)